@article{9e9dd4fbee6a4d42964d4bea03422e01,
title = "Isolation and characterization of actinoramides A-C, highly modified peptides from a marine Streptomyces sp.",
abstract = "Reported herein is the isolation and structure elucidation of three highly modified peptides, actinoramides A-C (1-3), which are produced by a marine bacterium closely related to the genus Streptomyces. The planar structures of the actinoramides, which are composed of the unusual amino acids 2-amino-4-ureidobutanoic acid and 4-amino-3-hydroxy-2-methyl-5-phenylpentanoic acid, were assigned by chemical transformations and by interpretation of spectroscopic data, while the absolute configuration of these new peptides were defined by application of the advanced Marfey's and Mosher's methods.",
keywords = "Advanced Marfey's method, Advanced Mosher's method, Marine Streptomyces, Peptide hydrolysis, Unusual amino acids",
author = "Nam, {Sang Jip} and Kauffman, {Christopher A.} and Jensen, {Paul R.} and William Fenical",
note = "Funding Information: Financial support was provided by the National Cancer Institute , NIH (under grant CA044848 ). We thank Dr. C.C. Hughes for his generous advice in the determination of stereochemistry of the actinoramides. We also thank Dr. D.-C. Oh (Harvard Medical School) for providing amino acids and Prof. T. Molinski (Department of Chemistry and Biochemistry, UCSD) for providing lobocyclamide B. We especially thank Dr. K.N. Maloney for providing the information for the strain CNQ-027, and Dr. J. Pezzuto (University of Hawaii, Hilo) for providing NF-κB and aromatase bioassay data. ",
year = "2011",
month = sep,
day = "2",
doi = "10.1016/j.tet.2011.04.051",
language = "English",
volume = "67",
pages = "6707--6712",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Ltd.",
number = "35",
}
