TY - JOUR
T1 - Ischemia-reperfusion alters cardiac lipoprotein lipase
AU - Pulinilkunnil, Thomas
AU - Puthanveetil, Prasanth
AU - Kim, Min Suk
AU - Wang, Fang
AU - Schmitt, Veronika
AU - Rodrigues, Brian
PY - 2010/2
Y1 - 2010/2
N2 - Ischemia-reperfusion (I/R) is associated with changes in energy metabolism in the heart. However, the majority of studies have focused on examining rates and extent of fatty acid (FA) oxidation, with limited emphasis on FA delivery. We examined the influence of acute myocardial I/R on coronary lipoprotein lipase (LPL), the key enzyme responsible for triglyceride-lipoprotein hydrolysis and FA delivery to the heart. In a whole animal and an ex vivo model of I/R, we demonstrate increases in luminal LPL activity, an effect that involved signaling through nitric oxide. Given the damaging effect of excess FA utilization by the ischemic heart, strategies to restrict LPL at the vascular lumen would be an attractive therapeutic option in limiting I/R related cardiac injury.
AB - Ischemia-reperfusion (I/R) is associated with changes in energy metabolism in the heart. However, the majority of studies have focused on examining rates and extent of fatty acid (FA) oxidation, with limited emphasis on FA delivery. We examined the influence of acute myocardial I/R on coronary lipoprotein lipase (LPL), the key enzyme responsible for triglyceride-lipoprotein hydrolysis and FA delivery to the heart. In a whole animal and an ex vivo model of I/R, we demonstrate increases in luminal LPL activity, an effect that involved signaling through nitric oxide. Given the damaging effect of excess FA utilization by the ischemic heart, strategies to restrict LPL at the vascular lumen would be an attractive therapeutic option in limiting I/R related cardiac injury.
KW - Ischemia
KW - LPL
KW - Myocytes
KW - NOS
KW - Reperfusion
UR - http://www.scopus.com/inward/record.url?scp=74149094032&partnerID=8YFLogxK
U2 - 10.1016/j.bbalip.2009.10.008
DO - 10.1016/j.bbalip.2009.10.008
M3 - Article
C2 - 19857601
AN - SCOPUS:74149094032
SN - 1388-1981
VL - 1801
SP - 171
EP - 175
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
IS - 2
ER -