Ischemia-reperfusion alters cardiac lipoprotein lipase

Thomas Pulinilkunnil, Prasanth Puthanveetil, Min Suk Kim, Fang Wang, Veronika Schmitt, Brian Rodrigues

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Ischemia-reperfusion (I/R) is associated with changes in energy metabolism in the heart. However, the majority of studies have focused on examining rates and extent of fatty acid (FA) oxidation, with limited emphasis on FA delivery. We examined the influence of acute myocardial I/R on coronary lipoprotein lipase (LPL), the key enzyme responsible for triglyceride-lipoprotein hydrolysis and FA delivery to the heart. In a whole animal and an ex vivo model of I/R, we demonstrate increases in luminal LPL activity, an effect that involved signaling through nitric oxide. Given the damaging effect of excess FA utilization by the ischemic heart, strategies to restrict LPL at the vascular lumen would be an attractive therapeutic option in limiting I/R related cardiac injury.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1801
Issue number2
DOIs
StatePublished - Feb 2010

Keywords

  • Ischemia
  • LPL
  • Myocytes
  • NOS
  • Reperfusion

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