TY - JOUR
T1 - Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
AU - Johnson, Richard J.
AU - Kang, Duk Hee
AU - Feig, Daniel
AU - Kivlighn, Salah
AU - Kanellis, John
AU - Watanabe, Susumu
AU - Tuttle, Katherine R.
AU - Rodriguez-Iturbe, Bernardo
AU - Herrera-Acosta, Jaime
AU - Mazzali, Marilda
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events. In this report, we review the epidemiologic evidence and potential mechanisms for this association. We also summarize experimental studies that demonstrate that uric acid is not inert but may have both beneficial functions (acting as an antioxidant) as well as detrimental actions (to stimulate vascular smooth muscle cell proliferation and induce endothelial dysfunction). A recently developed experimental model of mild hyperuricemia also provides the first provocative evidence that uric acid may have a pathogenic role in the development of hypertension, vascular disease, and renal disease. Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy.
AB - Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events. In this report, we review the epidemiologic evidence and potential mechanisms for this association. We also summarize experimental studies that demonstrate that uric acid is not inert but may have both beneficial functions (acting as an antioxidant) as well as detrimental actions (to stimulate vascular smooth muscle cell proliferation and induce endothelial dysfunction). A recently developed experimental model of mild hyperuricemia also provides the first provocative evidence that uric acid may have a pathogenic role in the development of hypertension, vascular disease, and renal disease. Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy.
KW - Antioxidants
KW - Cardiovascular diseases
KW - Hypertension, essential
KW - Renal disease
KW - Renin-angiotensin system
KW - Vascular diseases
UR - http://www.scopus.com/inward/record.url?scp=0038119701&partnerID=8YFLogxK
U2 - 10.1161/01.HYP.0000069700.62727.C5
DO - 10.1161/01.HYP.0000069700.62727.C5
M3 - Short survey
C2 - 12707287
AN - SCOPUS:0038119701
SN - 0194-911X
VL - 41
SP - 1183
EP - 1190
JO - Hypertension
JF - Hypertension
IS - 6
ER -