Abstract
A 69-year-old male underwent nephrectomy after presenting with a renal mass, as visualized through imaging. Histologic evaluation of the specimen revealed a papillary urothelial carcinoma (UC) in the renal pelvis with infiltration into the renal parenchyma that showed sarcomatoid and rhabdoid features; these features are typically associated with mixed inflammatory infiltrate, storiform fibrosis, and obliterative phlebitis, which is reminiscent of IgG4-related disease (IgG4-RD). Immunohistochemical labeling for IgG4 plasma cells showed that there were >50 cells in a single high-power field and the ratio of IgG4/IgG was >40%; these results are consistent with a diagnosis of IgG4-RD. Herein, we describe the first case of UC that has both sarcomatoid and rhabdoid features and high proportions of IgG4+ plasma cells.
Original language | English |
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Pages (from-to) | 4033-4037 |
Number of pages | 5 |
Journal | International Journal of Clinical and Experimental Pathology |
Volume | 9 |
Issue number | 3 |
State | Published - 2016 |
Bibliographical note
Funding Information:This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2013R1A1A- 1007658).
Keywords
- IgG4
- Plasma cell
- Rhabdoid
- Urothelial carcinoma