Is the association between ACE genes and blood pressure mediated by postnatal growth during the first 3 years?

Jung Won Min, Young Ju Kim, Hwayoung Lee, Eun Ae Park, Su Jin Cho, Young Mi Hong, Se Young Oh, Eunhee Ha, Duk Hee Kang, Hyesook Park

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Unlike the defined role of angiotensin-converting enzyme (ACE) gene in adult hypertension, ACE gene did not show direct influence on childhood blood pressure (BP), rather, seemed to be related to childhood growth with age-dependent characteristics. Thus, we examined intermediate effects of postnatal growth between the ACE polymorphisms and BP. We analyzed data from 257 children born in 2001-04 at Ewha Womans University Hospital in Seoul, Korea, and followed them up until 3. years of age. Children with excessive adiposity had higher BP, as rapid growers did to no-change and decelerated growers. The ACE II genotype was associated with greater growth acceleration than the DD genotype (II: 46.8% vs. DD: 23.9%), and with a higher BP. The interactions between ACE genotype and adiposity at age 3 were significant on the BP levels. The highest BP increase with the same degree of adiposity was observed in those with the II genotype [β (SE) for BMI: 1.9 (0.9), p= 0.04]; particularly, only rapid grown II carriers demonstrated statistical significance on this linear association. These results suggested that ACE polymorphisms and BP association are mediated by postnatal growth. Further studies are required to determine the age-specific ACE genetic effects and its undefined biological mechanism.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalEarly Human Development
Issue number6
StatePublished - Jun 2012

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government ( 2009-0064004 ).


  • ACE polymorphisms
  • Adiposity
  • Blood pressure
  • Postnatal growth


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