Is obstructive sleep apnea associated with the presence of intracranial cerebral atherosclerosis?

Tae Jin Song, Jung Hyun Park, Kang Hyun Choi, Ju Hee Kim, Yunseo Choi, Yoonkyung Chang, Hyeon Jin Kim, Jangsup Moon, Yong Jae Kim, Hyang Woon Lee

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Purpose: Intracranial cerebral atherosclerosis (ICAS) is one of critical atherosclerosis which closely related with stroke. Obstructive sleep apnea (OSA) is associated with systemic atherosclerosis, but it is unclear whether OSA is related with the presence of ICAS. We aimed to investigate the association between the presence of ICAS and severity of OSA in patients with suspected OSA. Methods: This retrospective, cross-sectional study included 283 patients who suspected OSA (presence of one or more OSA-related symptom and high-risk category in Berlin questionnaire) and underwent polysomnography and brain magnetic resonance angiography (MRA). The ICAS was defined as ≥50% decrease of luminal diameter in MRA. The severity of OSA was defined by apnea-hypopnea index (AHI). Results: The mean age was 60.7 ± 13.5 years, and 55.8% (158/283) were male in all included patients. The 53 (18.7%) patients had ICAS and 117 (41.3%) patients had moderate to severe OSA (AHI ≥ 15). Higher AHI was noted in patients with ICAS compared to those without ICAS (31.7 ± 25.8 versus 15.2 ± 17.4, p = 0.001). In multivariable logistic analyses, after adjusting for age, sex, and variables with p < 0.1 in univariable analyses (hypertension, diabetes mellitus, atrial fibrillation, previous stroke history, body mass index, lipid-lowing agents, arousal index, and minimum oxygen saturation), moderate to severe OSA were independently related with the presence of ICAS (odds ratio 4.17, 95% confidence interval 1.40–12.40, p = 0.010). Conclusions: Our findings suggest that moderate to severe OSA is associated with the presence of ICAS in patients with suspected OSA.

Original languageEnglish
Pages (from-to)639-646
Number of pages8
JournalSleep and Breathing
Issue number3
StatePublished - 1 Sep 2017

Bibliographical note

Publisher Copyright:
© 2017, Springer-Verlag Berlin Heidelberg.


  • Apnea-hypopnea index
  • Intracranial cerebral atherosclerosis
  • Obstructive sleep apnea


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