Irritable bowel syndrome-specific health-related quality of life instrument: Development and psychometric evaluation

Eun Hyun Lee, Oran Kwon, Ki Baik Hahm, Won Hee Kim, Jin Il Kim, Dae Young Cheung, Yoon Jae Kim, Jung Ho Kim, Jong Jae Park, Moon Kyung Joo

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background: Health-related quality of life (HRQOL) is an important outcome indicator for chronic disease, and particularly in the absence of biological markers for illness, such as with irritable bowel syndrome (IBS). The aims of this study were to develop and evaluate a new IBS-specific HRQOL instrument (IBS-HR-QOL). Methods: This methodological study comprised three steps: conceptualization of the IBS-HR-QOL, item extraction and establishment of content validity, and psychometric evaluation of the instrument with 267 IBS patients recruited from four university hospitals. Results: The content validity of the developed IBS-HR-QOL was assessed by 11 experts. Exploratory and confirmatory factor analyses yielded four factors. The criterion and convergent validities of the IBS-HR-QOL were demonstrated using the Short Form-36 and the Hospital Anxiety and Depression Scale, respectively. Known-groups validity was demonstrated using a symptom-severity scale. The internal consistency reliability and test-retest reliability were satisfactory, with a Cronbach's alpha and intraclass correlation coefficient of 0.93 and 0.88, respectively. Conclusions: The IBS-HR-QOL comprises a total of 16 items. The IBS-HR-QOL demonstrated good psychometric properties. This instrument is easily comprehensible and short, rendering it feasible for use in clinical practice and research.

Original languageEnglish
Article number22
Pages (from-to)11
Number of pages1
JournalHealth and Quality of Life Outcomes
Issue number1
StatePublished - 17 Feb 2016

Bibliographical note

Publisher Copyright:
© 2016 Lee et al.


  • Health-related quality of life
  • Irritable bowel syndrome
  • Reliability
  • Validity


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