The appropriate use of the data analysis method in a longitudinal design remains controversial in gerontological nursing research. The objective of the current study is to compare statistical approaches between a hierarchical-linear model (HLM) and a latent-growth model (LGM) in random eff ects, variance explained, growth trajectory, and model fi tness. Secondary analysis of longitudinal data was used. Two variables were chosen to demonstrate the comparison between statistical methods. The HLM was superior in addressing unbalanced data in repeated-measures analysis of variance (ANOVA) and multivariate ANOVA because its nested data structure and random eff ects could be estimated. The LGM had advantages in modeling growth trajectories and model-fi t comparisons. Superior to the HLM, the LGM reported more acceptable data fi t, reporting a quadratic model, and successfully diff erentiated between and within components. The current research provides some evidence for applying appropriate statistical methods when addressing longitudinal datasets in gerontological nursing research.