TY - JOUR
T1 - Investigating the Efficacy of Subharmonic Aided Pressure Estimation for Portal Vein Pressures and Portal Hypertension Monitoring
AU - Dave, Jaydev K.
AU - Halldorsdottir, Valgerdur G.
AU - Eisenbrey, John R.
AU - Merton, Daniel A.
AU - Liu, Ji Bin
AU - Zhou, Jian Hua
AU - Wang, Hsin Kai
AU - Park, Suhyun
AU - Dianis, Scott
AU - Chalek, Carl L.
AU - Lin, Feng
AU - Thomenius, Kai E.
AU - Brown, Daniel B.
AU - Forsberg, Flemming
N1 - Funding Information:
This study was supported by National Institutes of Health grants R21 HL081892 and RC1 DK087365 (supporting JRE) and US Army Medical Research & Material Command grant W81XWH-08-1-0503 (supporting VGH). The authors acknowledge the support of GE Healthcare, Oslo, Norway, for supplying Sonazoid.
PY - 2012/10
Y1 - 2012/10
N2 - The efficacy of using subharmonic emissions from Sonazoid microbubbles (GE Healthcare, Oslo, Norway) to track portal vein pressures and pressure changes was investigated in 14 canines using either slow- or high-flow models of portal hypertension (PH). A modified Logiq 9 scanner (GE Healthcare, Milwaukee, WI, USA) operating in subharmonic mode (ftransmit: 2.5 MHz, freceive: 1.25 MHz) was used to collect radiofrequency data at 10-40% incident acoustic power levels with 2-4 transmit cycles (in triplicate) before and after inducing PH. A pressure catheter (Millar Instruments, Inc., Houston, TX, USA) provided reference portal vein pressures. At optimum insonification, subharmonic signal amplitude changes correlated with portal vein pressure changes; r ranged from -0.82 to -0.94 and from -0.70 to -0.73 for PH models considered separately or together, respectively. The subharmonic signal amplitudes correlated with absolute portal vein pressures (r: -0.71 to -0.79). Statistically significant differences between subharmonic amplitudes, before and after inducing PH, were noted (p ≤ 0.01). Portal vein pressures estimated using subharmonic aided pressure estimation did not reveal significant differences (p > 0.05) with respect to the pressures obtained using the Millar pressure catheter. Subharmonic-aided pressure estimation may be useful clinically for portal vein pressure monitoring.
AB - The efficacy of using subharmonic emissions from Sonazoid microbubbles (GE Healthcare, Oslo, Norway) to track portal vein pressures and pressure changes was investigated in 14 canines using either slow- or high-flow models of portal hypertension (PH). A modified Logiq 9 scanner (GE Healthcare, Milwaukee, WI, USA) operating in subharmonic mode (ftransmit: 2.5 MHz, freceive: 1.25 MHz) was used to collect radiofrequency data at 10-40% incident acoustic power levels with 2-4 transmit cycles (in triplicate) before and after inducing PH. A pressure catheter (Millar Instruments, Inc., Houston, TX, USA) provided reference portal vein pressures. At optimum insonification, subharmonic signal amplitude changes correlated with portal vein pressure changes; r ranged from -0.82 to -0.94 and from -0.70 to -0.73 for PH models considered separately or together, respectively. The subharmonic signal amplitudes correlated with absolute portal vein pressures (r: -0.71 to -0.79). Statistically significant differences between subharmonic amplitudes, before and after inducing PH, were noted (p ≤ 0.01). Portal vein pressures estimated using subharmonic aided pressure estimation did not reveal significant differences (p > 0.05) with respect to the pressures obtained using the Millar pressure catheter. Subharmonic-aided pressure estimation may be useful clinically for portal vein pressure monitoring.
KW - Noninvasive pressure estimation
KW - Portal hypertension
KW - Subharmonic imaging
KW - Subharmonic-aided pressure estimation
KW - Ultrasound contrast agents
UR - http://www.scopus.com/inward/record.url?scp=84865761072&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2012.06.013
DO - 10.1016/j.ultrasmedbio.2012.06.013
M3 - Article
C2 - 22920550
AN - SCOPUS:84865761072
SN - 0301-5629
VL - 38
SP - 1784
EP - 1798
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 10
ER -