Investigating gene function using mouse models

Daekee Lee, David W. Threadgill

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Mouse models have become central to investigating and understanding mammalian gene function. Since the development of the first transgenic and knockout models, new methods have been envisioned that both simplify and increase the specificity of mouse models. Combinations of genetic tools have also been applied to dissect gene activities and to provide systems that are both spatially and temporally regulated. Furthermore, novel technologies have been developed that can regulate biological information at each level from creating specific modifications in DNA, to inhibiting gene transcription, to regulating protein activity.

Original languageEnglish
Pages (from-to)246-252
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number3
StatePublished - Jun 2004


  • BAC
  • Cbfb
  • Cdk2
  • ES
  • MEF
  • P
  • P1-derived artificial chromosomes
  • PAC
  • RB
  • RNAi
  • bacterial artificial chromosome
  • core-binding factor β
  • cyclin-dependent kinase 2
  • days post coitum
  • dpc
  • embryonic stem
  • mouse embryonic fibroblast
  • post-natal day
  • retinoblastoma


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