Intracellular Glucose-Depriving Polymer Micelles for Antiglycolytic Cancer Treatment

Jangwook Lee, Kwangmeyung Kim, Ick Chan Kwon, Kuen Yong Lee

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A new anticancer strategy to exploit abnormal metabolism of cancer cells rather than to merely control the drug release or rearrange the tumor microenvironment is reported. An antiglycolytic amphiphilic polymer, designed considering the unique metabolism of cancer cells (Warburg effect) and aimed at the regulation of glucose metabolism, is synthesized through chemical conjugation between glycol chitosan (GC) and phenylboronic acid (PBA). GC-PBA derivatives form stable micellar structures under physiological conditions and respond to changes in glucose concentration. Once the micelles accumulate at the tumor site, intracellular glucose capture occurs, and the resultant energy deprivation through the inhibition of aerobic glycolysis remarkably suppresses tumor growth without significant side effects in vivo. This strategy highlights the need to develop safe and effective cancer treatment without the use of conventional anticancer drugs.

Original languageEnglish
Article number2207342
JournalAdvanced Materials
Volume35
Issue number10
DOIs
StatePublished - 9 Mar 2023

Bibliographical note

Funding Information:
This study was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF‐2020R1A2C1012199). J.L. acknowledges the Korea Research Institute of Bioscience and Biotechnology (KRIBB) Research Initiative Program (KGM5272221).

Publisher Copyright:
© 2023 Wiley-VCH GmbH.

Keywords

  • apoptosis
  • cancer therapy
  • glucose-responsive polymers
  • induced energy deficiency
  • nutrient deprivation

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