Abstract
Interleukin-2 plays a significant role in T cell proliferation. Here, we report the role of IL-2 in angiogenesis. IL-2 increased the ROS level and phosphorylation of Akt in human umbilical vein endothetial cells (HUVECs). IL-2 increased angiogenesis in an animal model and tube formation in HUVECs. The effect of IL-2 on angiogenesis and tube formation was mediated by ROS and Akt. This is the first report that IL-2 promotes angiogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 377-382 |
| Number of pages | 6 |
| Journal | Journal of Microbiology and Biotechnology |
| Volume | 18 |
| Issue number | 2 |
| State | Published - 28 Feb 2008 |
Keywords
- Angiogenesis
- Interleukin-2
- Reactive oxygen species
- Serine/threonine kinase Akt