Intellect declines in healthy elderly subjects and cerebellum

Jun Young Lee, In Kyoon Lyoo, Seon Uk Kim, Hong Suk Jang, Dong Woo Lee, Hong Jin Jeon, Sang Chul Park, Maeng Je Cho

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Scores of the performance scale of the Wechsler Adult Intelligence Scale (WAIS) declined linearly with age from the 6th decade, whereas those of the verbal scale did not. This decrease in performance intelligence was thought to be related to an age-related frontal atrophy. The relationship between scores of the WAIS and changes in regional cortical gray matter density were examined in healthy elderly subjects using voxel-based morphometry. Thirty healthy non-demented individuals >50 years of age were tested with the WAIS and scanned with brain magnetic resonance imaging (MRI). The right neocerebellum was significantly associated with scores of the performance intelligence scale while frontal lobes were not. The current study suggests that the cerebellum may play an important role in changes of intellectual capacity in old age.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalPsychiatry and Clinical Neurosciences
Issue number1
StatePublished - Feb 2005


  • Aging
  • Cerebellum
  • Cognition
  • Intelligence
  • Magnetic resonance imaging
  • Voxel-based morphometry


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