Integrated NASBA array for drug screening and expression profiling

Ivan K. Dimov; Luke P. Lee

Integrated NASBA array for drug screening and expression profiling

Ivan K. Dimov, Luke P. Lee

Department of Chemistry & Nanoscience

Research output: Contribution to conference › Paper › peer-review

1 Scopus citations

Abstract

We present the design and development of a novel integrated microfluidic NASBA array that includes microfluidic dynamic cell culture, cell stimulation, cell labeling, lysis, and real-time Nucleic-Acid-Sequence-Based-Amplification (NASBA) based RNA analysis on a single chip. By multiplexing this integrated functionality the device can be used for high content screening, gene expression profiling, and biomedical diagnostic applications.

Original language	English
Pages	640-642
Number of pages	3
State	Published - 2008
Event	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States Duration: 12 Oct 2008 → 16 Oct 2008

Conference

Conference	12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
Country/Territory	United States
City	San Diego, CA
Period	12/10/08 → 16/10/08

Keywords

Array
Cell culture
Gene profiling
Microfluific
NASBA

Cite this

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title = "Integrated NASBA array for drug screening and expression profiling",

abstract = "We present the design and development of a novel integrated microfluidic NASBA array that includes microfluidic dynamic cell culture, cell stimulation, cell labeling, lysis, and real-time Nucleic-Acid-Sequence-Based-Amplification (NASBA) based RNA analysis on a single chip. By multiplexing this integrated functionality the device can be used for high content screening, gene expression profiling, and biomedical diagnostic applications.",

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AU - Lee, Luke P.

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N2 - We present the design and development of a novel integrated microfluidic NASBA array that includes microfluidic dynamic cell culture, cell stimulation, cell labeling, lysis, and real-time Nucleic-Acid-Sequence-Based-Amplification (NASBA) based RNA analysis on a single chip. By multiplexing this integrated functionality the device can be used for high content screening, gene expression profiling, and biomedical diagnostic applications.

AB - We present the design and development of a novel integrated microfluidic NASBA array that includes microfluidic dynamic cell culture, cell stimulation, cell labeling, lysis, and real-time Nucleic-Acid-Sequence-Based-Amplification (NASBA) based RNA analysis on a single chip. By multiplexing this integrated functionality the device can be used for high content screening, gene expression profiling, and biomedical diagnostic applications.

KW - Array

KW - Cell culture

KW - Gene profiling

KW - Microfluific

KW - NASBA

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M3 - Paper

AN - SCOPUS:84902464143

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EP - 642

T2 - 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008

Y2 - 12 October 2008 through 16 October 2008

ER -

Integrated NASBA array for drug screening and expression profiling

Abstract

Conference

Keywords

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