@inproceedings{f7d01e57e84d41179a616e36f190ff08,
title = "Integrated microfluidic platform with nanoplasmonic aptasensor for cancer research",
abstract = "In this paper, we propose an integrated microfluidic platform utilizing aptamer and surface plasmonics for a long-term and real-time assessment and label-free detection of secreted growth factors under the spatial and temporal control of a chemically simulated tumor microenvironment. The integrated platform achieved detection of vascular endothelial growth factor (VEGF) down to 1 nM in buffer solution and also VEGF secreted from MCF-7 (human breast cancer) cells upon continuous stimulation with 0.1 mM estrodiole for 37 hrs. The integrated microfluidic platform may be useful for the application to cell-based screening and high-throughput investigation of drug candidates that inhibit VEGF secretion.",
keywords = "Aptamer, Breast cancer, Integration, Microfluidics, Plasmonics",
author = "Hansang Cho and Yolanda Zhang and Brian Lee and Audrey Kimteng and Bearinger, {Jane P.} and Baker, {Brian R.} and Laurence, {Ted A.} and Lane, {Stephen M.} and Lee, {Luke P.}",
year = "2009",
language = "English",
isbn = "9780979806421",
series = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "1482--1484",
booktitle = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
note = "13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 ; Conference date: 01-11-2009 Through 05-11-2009",
}
