Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women

Seungyoun Jung; Olga Goloubeva; Nola Hylton; Catherine Klifa; Erin LeBlanc; John Shepherd; Linda Snetselaar; Linda Van Horn; Joanne F. Dorgan

doi:10.1007/s10552-018-1040-1

Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women

Seungyoun Jung, Olga Goloubeva, Nola Hylton, Catherine Klifa, Erin LeBlanc, John Shepherd, Linda Snetselaar, Linda Van Horn, Joanne F. Dorgan

Department of Nutritional Science & Food Management

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Purpose: Carbohydrate intake increases postprandial insulin secretion and may affect breast density, a strong risk factor for breast cancer, early in life. We examined associations of adolescent and early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars with breast density among 182 young women. Methods: Diet was assessed using three 24-h recalls at each of five Dietary Intervention Study in Children (DISC) clinic visits when participants were age 10–19 years and at the DISC06 Follow-Up Study clinic visit when participants were age 25–29 years. Associations between energy-adjusted carbohydrates and MRI-measured percent dense breast volume (%DBV) and absolute dense breast volume (ADBV) at 25–29 years were quantified using multivariable-adjusted mixed-effects linear models. Results: Adolescent sucrose intakes and premenarcheal total carbohydrates intakes were modestly associated with higher %DBV (mean %DBV_{Q1 vs Q4}, 16.6 vs 23.5% for sucrose; and 17.2 vs 22.3% for premenarcheal total carbohydrates, all P_trend ≤ 0.02), but not with ADBV. However, adolescent intakes of fiber and fructose were not associated with %DBV and ADBV. Early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars were not associated with %DBV and ADBV. Conclusions: Insulinemic carbohydrate diet during puberty may be associated with adulthood breast density, but our findings need replication in larger studies. Clinical Trials Registration ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.

Original language	English
Pages (from-to)	631-642
Number of pages	12
Journal	Cancer Causes and Control
Volume	29
Issue number	7
DOIs	https://doi.org/10.1007/s10552-018-1040-1
State	Published - 1 Jul 2018

Bibliographical note

Funding Information:
Acknowledgments This work was supported by grants from the National Cancer Institute [R01CA104670 and R03 CA167764 to J.F. Dorgan] and American Institute for Cancer Research [AICR #204113 to J.F. Dorgan] and by cooperative agreements from the National Heart, Lung, and Blood Institute [U01-HL37947 to L. Van Horn, U01-HL37948 to B.A. Barton, U01-HL37954 to V.J. Stevens, U01-HL37962 to R.M. Lauer, U01-37966 to N.L. Lasser, U01-HL37975 to P.O. Kwiterovich, and U01-HL38110 to A.M. Robson].

Publisher Copyright:
© 2018, Springer International Publishing AG, part of Springer Nature.

Keywords

Absolute dense breast volume
Absolute non-dense breast volume
Breast cancer
Breast density
Carbohydrate
Fiber
Fructose
Glycemic index
Glycemic load
Sucrose
Timing of exposure
Young women

Access to Document

10.1007/s10552-018-1040-1

Cite this

@article{a60117684b7846008aba4763b6884fa1,

title = "Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women",

abstract = "Purpose: Carbohydrate intake increases postprandial insulin secretion and may affect breast density, a strong risk factor for breast cancer, early in life. We examined associations of adolescent and early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars with breast density among 182 young women. Methods: Diet was assessed using three 24-h recalls at each of five Dietary Intervention Study in Children (DISC) clinic visits when participants were age 10–19 years and at the DISC06 Follow-Up Study clinic visit when participants were age 25–29 years. Associations between energy-adjusted carbohydrates and MRI-measured percent dense breast volume (%DBV) and absolute dense breast volume (ADBV) at 25–29 years were quantified using multivariable-adjusted mixed-effects linear models. Results: Adolescent sucrose intakes and premenarcheal total carbohydrates intakes were modestly associated with higher %DBV (mean %DBVQ1 vs Q4, 16.6 vs 23.5% for sucrose; and 17.2 vs 22.3% for premenarcheal total carbohydrates, all Ptrend ≤ 0.02), but not with ADBV. However, adolescent intakes of fiber and fructose were not associated with %DBV and ADBV. Early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars were not associated with %DBV and ADBV. Conclusions: Insulinemic carbohydrate diet during puberty may be associated with adulthood breast density, but our findings need replication in larger studies. Clinical Trials Registration ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.",

keywords = "Absolute dense breast volume, Absolute non-dense breast volume, Breast cancer, Breast density, Carbohydrate, Fiber, Fructose, Glycemic index, Glycemic load, Sucrose, Timing of exposure, Young women",

author = "Seungyoun Jung and Olga Goloubeva and Nola Hylton and Catherine Klifa and Erin LeBlanc and John Shepherd and Linda Snetselaar and {Van Horn}, Linda and Dorgan, {Joanne F.}",

note = "Funding Information: Acknowledgments This work was supported by grants from the National Cancer Institute [R01CA104670 and R03 CA167764 to J.F. Dorgan] and American Institute for Cancer Research [AICR #204113 to J.F. Dorgan] and by cooperative agreements from the National Heart, Lung, and Blood Institute [U01-HL37947 to L. Van Horn, U01-HL37948 to B.A. Barton, U01-HL37954 to V.J. Stevens, U01-HL37962 to R.M. Lauer, U01-37966 to N.L. Lasser, U01-HL37975 to P.O. Kwiterovich, and U01-HL38110 to A.M. Robson]. Publisher Copyright: {\textcopyright} 2018, Springer International Publishing AG, part of Springer Nature.",

year = "2018",

month = jul,

day = "1",

doi = "10.1007/s10552-018-1040-1",

language = "English",

volume = "29",

pages = "631--642",

journal = "Cancer Causes and Control",

issn = "0957-5243",

publisher = "Springer Netherlands",

number = "7",

}

TY - JOUR

T1 - Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women

AU - Jung, Seungyoun

AU - Goloubeva, Olga

AU - Hylton, Nola

AU - Klifa, Catherine

AU - LeBlanc, Erin

AU - Shepherd, John

AU - Snetselaar, Linda

AU - Van Horn, Linda

AU - Dorgan, Joanne F.

N1 - Funding Information: Acknowledgments This work was supported by grants from the National Cancer Institute [R01CA104670 and R03 CA167764 to J.F. Dorgan] and American Institute for Cancer Research [AICR #204113 to J.F. Dorgan] and by cooperative agreements from the National Heart, Lung, and Blood Institute [U01-HL37947 to L. Van Horn, U01-HL37948 to B.A. Barton, U01-HL37954 to V.J. Stevens, U01-HL37962 to R.M. Lauer, U01-37966 to N.L. Lasser, U01-HL37975 to P.O. Kwiterovich, and U01-HL38110 to A.M. Robson]. Publisher Copyright: © 2018, Springer International Publishing AG, part of Springer Nature.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Purpose: Carbohydrate intake increases postprandial insulin secretion and may affect breast density, a strong risk factor for breast cancer, early in life. We examined associations of adolescent and early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars with breast density among 182 young women. Methods: Diet was assessed using three 24-h recalls at each of five Dietary Intervention Study in Children (DISC) clinic visits when participants were age 10–19 years and at the DISC06 Follow-Up Study clinic visit when participants were age 25–29 years. Associations between energy-adjusted carbohydrates and MRI-measured percent dense breast volume (%DBV) and absolute dense breast volume (ADBV) at 25–29 years were quantified using multivariable-adjusted mixed-effects linear models. Results: Adolescent sucrose intakes and premenarcheal total carbohydrates intakes were modestly associated with higher %DBV (mean %DBVQ1 vs Q4, 16.6 vs 23.5% for sucrose; and 17.2 vs 22.3% for premenarcheal total carbohydrates, all Ptrend ≤ 0.02), but not with ADBV. However, adolescent intakes of fiber and fructose were not associated with %DBV and ADBV. Early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars were not associated with %DBV and ADBV. Conclusions: Insulinemic carbohydrate diet during puberty may be associated with adulthood breast density, but our findings need replication in larger studies. Clinical Trials Registration ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.

AB - Purpose: Carbohydrate intake increases postprandial insulin secretion and may affect breast density, a strong risk factor for breast cancer, early in life. We examined associations of adolescent and early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars with breast density among 182 young women. Methods: Diet was assessed using three 24-h recalls at each of five Dietary Intervention Study in Children (DISC) clinic visits when participants were age 10–19 years and at the DISC06 Follow-Up Study clinic visit when participants were age 25–29 years. Associations between energy-adjusted carbohydrates and MRI-measured percent dense breast volume (%DBV) and absolute dense breast volume (ADBV) at 25–29 years were quantified using multivariable-adjusted mixed-effects linear models. Results: Adolescent sucrose intakes and premenarcheal total carbohydrates intakes were modestly associated with higher %DBV (mean %DBVQ1 vs Q4, 16.6 vs 23.5% for sucrose; and 17.2 vs 22.3% for premenarcheal total carbohydrates, all Ptrend ≤ 0.02), but not with ADBV. However, adolescent intakes of fiber and fructose were not associated with %DBV and ADBV. Early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars were not associated with %DBV and ADBV. Conclusions: Insulinemic carbohydrate diet during puberty may be associated with adulthood breast density, but our findings need replication in larger studies. Clinical Trials Registration ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.

KW - Absolute dense breast volume

KW - Absolute non-dense breast volume

KW - Breast cancer

KW - Breast density

KW - Carbohydrate

KW - Fiber

KW - Fructose

KW - Glycemic index

KW - Glycemic load

KW - Sucrose

KW - Timing of exposure

KW - Young women

UR - http://www.scopus.com/inward/record.url?scp=85047407453&partnerID=8YFLogxK

U2 - 10.1007/s10552-018-1040-1

DO - 10.1007/s10552-018-1040-1

M3 - Article

C2 - 29802491

AN - SCOPUS:85047407453

SN - 0957-5243

VL - 29

SP - 631

EP - 642

JO - Cancer Causes and Control

JF - Cancer Causes and Control

IS - 7

ER -

Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this