TY - JOUR
T1 - Insertion/deletion polymorphism of angiotensin converting enzyme gene in Kawasaki disease
AU - Yoon, Hee Shim
AU - Hae, Soon Kim
AU - Sohn, Sejung
AU - Young, Mi Hong
PY - 2006/4
Y1 - 2006/4
N2 - Polymorphism of angiotensin converting enzyme (ACE) gene is reported to be associated with ischemic heart disease, hypertrophic cardiomyopathy, and idiopathic dilated cardiomyopathy. In this study, we investigated the relationship between Kawasaki disease and insertion/deletion polymorphism of ACE gene. Fifty five Kawasaki disease patients and 43 healthy children were enrolled. ACE genotype was evaluated from each of the subjects' DNA fragments through polymerase chain reaction (PCR). Frequencies of ACE genotypes (DD, ID, II) were 12.7%, 60.0%, 27.3% in Kawasaki group, and 41.9%, 30.2%, 27.9% in control group respectively, indicating low rate of DD and high rate of ID genotype among Kawasaki patients (p<0.01). Comparing allelic (I, D) frequencies, I allele was more prevalent in Kawasaki group than in control group (57.3% vs. 43.0%, p<0.05). In Kawasaki group, both genotype and allelic frequencies were not statistically different between those with coronary dilatations and those without. ACE gene I/D polymorphism is thought to be associated with Kawasaki disease but not with the development of coronary dilatations.
AB - Polymorphism of angiotensin converting enzyme (ACE) gene is reported to be associated with ischemic heart disease, hypertrophic cardiomyopathy, and idiopathic dilated cardiomyopathy. In this study, we investigated the relationship between Kawasaki disease and insertion/deletion polymorphism of ACE gene. Fifty five Kawasaki disease patients and 43 healthy children were enrolled. ACE genotype was evaluated from each of the subjects' DNA fragments through polymerase chain reaction (PCR). Frequencies of ACE genotypes (DD, ID, II) were 12.7%, 60.0%, 27.3% in Kawasaki group, and 41.9%, 30.2%, 27.9% in control group respectively, indicating low rate of DD and high rate of ID genotype among Kawasaki patients (p<0.01). Comparing allelic (I, D) frequencies, I allele was more prevalent in Kawasaki group than in control group (57.3% vs. 43.0%, p<0.05). In Kawasaki group, both genotype and allelic frequencies were not statistically different between those with coronary dilatations and those without. ACE gene I/D polymorphism is thought to be associated with Kawasaki disease but not with the development of coronary dilatations.
KW - Angiotensin Converting Enzyme
KW - Kawasaki Disease
KW - Mucocutaneous Lymph Node Syndrome
KW - Peptidyl-Dipeptidase A
KW - Polymorphism, Genetic
UR - http://www.scopus.com/inward/record.url?scp=33646760663&partnerID=8YFLogxK
U2 - 10.3346/jkms.2006.21.2.208
DO - 10.3346/jkms.2006.21.2.208
M3 - Article
C2 - 16614502
AN - SCOPUS:33646760663
SN - 1011-8934
VL - 21
SP - 208
EP - 211
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
IS - 2
ER -