TY - JOUR
T1 - Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy
AU - Li, Xingshu
AU - Kwon, Nahyun
AU - Guo, Tian
AU - Liu, Zhuang
AU - Yoon, Juyoung
N1 - Funding Information:
J.Y. is thankful for financial support from the National Research Foundation of Korea (NRF), which is funded by the government of Korea (MSIP) (No. 2012R1A3A2048814). Z.L. is thankful for the financial support from the National Research Programs from Ministry of Science and Technology (MOST) of China (2016YFA0201200), the National Natural Science Foundation of China (51525203, 51761145041), Collaborative Innovation Center of Suzhou Nano Science and Technology, and a Project Funded by the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions.
Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/9/3
Y1 - 2018/9/3
N2 - Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback associated with its oxygen-dependent nature, which limits its effective use against hypoxic tumors. Moreover, both PDT-mediated oxygen consumption and microvascular damage further increase tumor hypoxia and, thus, impede therapeutic outcomes. In recent years, numerous investigations have focused on strategies for overcoming this drawback of PDT. These efforts, which are summarized in this review, have produced many innovative methods to avoid the limits of PDT associated with hypoxia.
AB - Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback associated with its oxygen-dependent nature, which limits its effective use against hypoxic tumors. Moreover, both PDT-mediated oxygen consumption and microvascular damage further increase tumor hypoxia and, thus, impede therapeutic outcomes. In recent years, numerous investigations have focused on strategies for overcoming this drawback of PDT. These efforts, which are summarized in this review, have produced many innovative methods to avoid the limits of PDT associated with hypoxia.
KW - hypoxia
KW - oxygen delivery
KW - photodynamic therapy
KW - tumors
UR - http://www.scopus.com/inward/record.url?scp=85050453899&partnerID=8YFLogxK
U2 - 10.1002/anie.201805138
DO - 10.1002/anie.201805138
M3 - Review article
C2 - 29808948
AN - SCOPUS:85050453899
SN - 1433-7851
VL - 57
SP - 11522
EP - 11531
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 36
ER -