Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy

Xingshu Li, Nahyun Kwon, Tian Guo, Zhuang Liu, Juyoung Yoon

Research output: Contribution to journalReview articlepeer-review

583 Scopus citations

Abstract

Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback associated with its oxygen-dependent nature, which limits its effective use against hypoxic tumors. Moreover, both PDT-mediated oxygen consumption and microvascular damage further increase tumor hypoxia and, thus, impede therapeutic outcomes. In recent years, numerous investigations have focused on strategies for overcoming this drawback of PDT. These efforts, which are summarized in this review, have produced many innovative methods to avoid the limits of PDT associated with hypoxia.

Original languageEnglish
Pages (from-to)11522-11531
Number of pages10
JournalAngewandte Chemie - International Edition
Volume57
Issue number36
DOIs
StatePublished - 3 Sep 2018

Keywords

  • hypoxia
  • oxygen delivery
  • photodynamic therapy
  • tumors

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