Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy

Xingshu Li, Nahyun Kwon, Tian Guo, Zhuang Liu, Juyoung Yoon

Research output: Contribution to journalReview articlepeer-review

810 Scopus citations


Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback associated with its oxygen-dependent nature, which limits its effective use against hypoxic tumors. Moreover, both PDT-mediated oxygen consumption and microvascular damage further increase tumor hypoxia and, thus, impede therapeutic outcomes. In recent years, numerous investigations have focused on strategies for overcoming this drawback of PDT. These efforts, which are summarized in this review, have produced many innovative methods to avoid the limits of PDT associated with hypoxia.

Original languageEnglish
Pages (from-to)11522-11531
Number of pages10
JournalAngewandte Chemie - International Edition
Issue number36
StatePublished - 3 Sep 2018

Bibliographical note

Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim


  • hypoxia
  • oxygen delivery
  • photodynamic therapy
  • tumors


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