Injectable thermogel for 3D culture of stem cells

Madhumita Patel, Hyun Jung Lee, Sohee Park, Yelin Kim, Byeongmoon Jeong

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations

Abstract

Thermogel is an aqueous polymer solution that undergoes sol-to-gel transition as the temperature increases. Cells, growth factors, and signaling molecules can be incorporated simultaneously during the sol-to-gel transition. The cytocompatible procedure makes the thermogel an excellent platform for 3D culture of stem cells. This review focuses on the crucial questions that need to be addressed to achieve effective differentiation of stem cells into target cells, comprising low modulus, cell adhesion, and controlled supply of the growth factors. Recent progress in the use of thermogel as a 3D culture system of stem cells is summarized, and our perspectives on designing a new thermogel for 3D culture and its eventual application to injectable tissue engineering of stem cells are presented.

Original languageEnglish
Pages (from-to)91-107
Number of pages17
JournalBiomaterials
Volume159
DOIs
StatePublished - Mar 2018

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government ( 2017R1A2B2007356 , 2017R1A5A1015365 , and 2014M3A9B6034223 ). MP and HJL equally contributed to this paper. All authors have given approval to the final version of the manuscript.

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

  • 3D culture
  • Stem cell
  • Temperature-sensitivity
  • Thermogel
  • Tissue engineering

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