Injectable polysaccharide microcapsules for prolonged release of minocycline for the treatment of periodontitis

Yoon Jeong Park; Jue Yeon Lee; Hey Ri Yeom; Kyung Hwa Kim; Sang Chul Lee; In Kyoung Shim; Chong Pyoung Chung; Seung Jin Lee

doi:10.1007/s10529-005-3550-7

Injectable polysaccharide microcapsules for prolonged release of minocycline for the treatment of periodontitis

Yoon Jeong Park, Jue Yeon Lee, Hey Ri Yeom, Kyung Hwa Kim, Sang Chul Lee, In Kyoung Shim, Chong Pyoung Chung, Seung Jin Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Injectable polysaccharide microcapsules holding minocycline were fabricated from alginate and chitosan for the treatment of periodontitis. The microcapsules were examined for the release and degradation of minocycline, as well as antimicrobial activity. The microcapsules were biodegradable and released minocycline between 10 and 1000 μg ml^-1, which was higher than the usual therapeutic concentration (1-5 μg ml^-1), for up to 7 days. These microcapsules showed a statistically significant suppression of pathogenic bacteria, such as Prevotella intermedia causing periodontitis. The microcapsules are thus potentially useful for drug delivery for the treatment of periodontitis.

Original language	English
Pages (from-to)	1761-1766
Number of pages	6
Journal	Biotechnology Letters
Volume	27
Issue number	22
DOIs	https://doi.org/10.1007/s10529-005-3550-7
State	Published - Nov 2005

Bibliographical note

Funding Information:
This research was supported by the grant from Korea Science and Engineering Foundation (KOSEF) through Intellectual Biointerface Engineering Center (IBEC) at Seoul National University, Korea.

Keywords

Controlled release
Injectable microcapsules
Minocycline
Periodontitis
Polysaccharide

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10.1007/s10529-005-3550-7

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title = "Injectable polysaccharide microcapsules for prolonged release of minocycline for the treatment of periodontitis",

abstract = "Injectable polysaccharide microcapsules holding minocycline were fabricated from alginate and chitosan for the treatment of periodontitis. The microcapsules were examined for the release and degradation of minocycline, as well as antimicrobial activity. The microcapsules were biodegradable and released minocycline between 10 and 1000 μg ml-1, which was higher than the usual therapeutic concentration (1-5 μg ml-1), for up to 7 days. These microcapsules showed a statistically significant suppression of pathogenic bacteria, such as Prevotella intermedia causing periodontitis. The microcapsules are thus potentially useful for drug delivery for the treatment of periodontitis.",

keywords = "Controlled release, Injectable microcapsules, Minocycline, Periodontitis, Polysaccharide",

author = "Park, {Yoon Jeong} and Lee, {Jue Yeon} and Yeom, {Hey Ri} and Kim, {Kyung Hwa} and Lee, {Sang Chul} and Shim, {In Kyoung} and Chung, {Chong Pyoung} and Lee, {Seung Jin}",

note = "Funding Information: This research was supported by the grant from Korea Science and Engineering Foundation (KOSEF) through Intellectual Biointerface Engineering Center (IBEC) at Seoul National University, Korea.",

year = "2005",

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doi = "10.1007/s10529-005-3550-7",

language = "English",

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AU - Park, Yoon Jeong

AU - Lee, Jue Yeon

AU - Yeom, Hey Ri

AU - Kim, Kyung Hwa

AU - Lee, Sang Chul

AU - Shim, In Kyoung

AU - Chung, Chong Pyoung

AU - Lee, Seung Jin

N1 - Funding Information: This research was supported by the grant from Korea Science and Engineering Foundation (KOSEF) through Intellectual Biointerface Engineering Center (IBEC) at Seoul National University, Korea.

PY - 2005/11

Y1 - 2005/11

N2 - Injectable polysaccharide microcapsules holding minocycline were fabricated from alginate and chitosan for the treatment of periodontitis. The microcapsules were examined for the release and degradation of minocycline, as well as antimicrobial activity. The microcapsules were biodegradable and released minocycline between 10 and 1000 μg ml-1, which was higher than the usual therapeutic concentration (1-5 μg ml-1), for up to 7 days. These microcapsules showed a statistically significant suppression of pathogenic bacteria, such as Prevotella intermedia causing periodontitis. The microcapsules are thus potentially useful for drug delivery for the treatment of periodontitis.

AB - Injectable polysaccharide microcapsules holding minocycline were fabricated from alginate and chitosan for the treatment of periodontitis. The microcapsules were examined for the release and degradation of minocycline, as well as antimicrobial activity. The microcapsules were biodegradable and released minocycline between 10 and 1000 μg ml-1, which was higher than the usual therapeutic concentration (1-5 μg ml-1), for up to 7 days. These microcapsules showed a statistically significant suppression of pathogenic bacteria, such as Prevotella intermedia causing periodontitis. The microcapsules are thus potentially useful for drug delivery for the treatment of periodontitis.

KW - Controlled release

KW - Injectable microcapsules

KW - Minocycline

KW - Periodontitis

KW - Polysaccharide

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JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 22

ER -

Injectable polysaccharide microcapsules for prolonged release of minocycline for the treatment of periodontitis

Abstract

Bibliographical note

Keywords

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