Injectable polysaccharide microcapsules for prolonged release of minocycline for the treatment of periodontitis

Yoon Jeong Park, Jue Yeon Lee, Hey Ri Yeom, Kyung Hwa Kim, Sang Chul Lee, In Kyoung Shim, Chong Pyoung Chung, Seung Jin Lee

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Injectable polysaccharide microcapsules holding minocycline were fabricated from alginate and chitosan for the treatment of periodontitis. The microcapsules were examined for the release and degradation of minocycline, as well as antimicrobial activity. The microcapsules were biodegradable and released minocycline between 10 and 1000 μg ml-1, which was higher than the usual therapeutic concentration (1-5 μg ml-1), for up to 7 days. These microcapsules showed a statistically significant suppression of pathogenic bacteria, such as Prevotella intermedia causing periodontitis. The microcapsules are thus potentially useful for drug delivery for the treatment of periodontitis.

Original languageEnglish
Pages (from-to)1761-1766
Number of pages6
JournalBiotechnology Letters
Volume27
Issue number22
DOIs
StatePublished - Nov 2005

Keywords

  • Controlled release
  • Injectable microcapsules
  • Minocycline
  • Periodontitis
  • Polysaccharide

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