Injectable gel: Poly(ethylene glycol)-sebacic acid polyester

Jisun Lee; Min Kyung Joo; Hejin Oh; Youn Soo Sohn; Byeongmoon Jeong

doi:10.1016/j.polymer.2006.03.109

Injectable gel: Poly(ethylene glycol)-sebacic acid polyester

Jisun Lee, Min Kyung Joo, Hejin Oh, Youn Soo Sohn, Byeongmoon Jeong

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

In order to develop an injectable material for drug delivery that has both formulation advantages of a sol-to-gel transition system and minimal burst release of a drug, a soft thermogel of poly(ethylene glycol)-sebacic acid polyester was synthesized. The polymer aqueous solution (25 wt%) undergoes 'clear sol-to-gel' transition as the temperature increases from 5 to 65 °C. The drug can be mixed in a low viscous sol state at low temperature (<15 °C). In particular, the thermogel is soft enough to be injected through a 21-gauge syringe needle even as a gel state. The model hydrophilic drug, FITC-dextran (molecular weight: 40,000 Da), was released from the gel over 24 h. The biodegradable poly(ethylene glycol)-sebacic acid polyester soft thermogel is believed to be promising for the hydrophilic drug delivery where an initial burst of a drug might be a concern.

Original language	English
Pages (from-to)	3760-3766
Number of pages	7
Journal	Polymer
Volume	47
Issue number	11
DOIs	https://doi.org/10.1016/j.polymer.2006.03.109
State	Published - 17 May 2006

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant (KRF-2004-005-C00090), SRC program of MOST/KOSEF through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (R11-2005-008-00000-0), and Ministry of Commerce, Industry, and Energy of Korea.

Keywords

Biodegradable polymer
Drug delivery
Sol-gel transition

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10.1016/j.polymer.2006.03.109

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title = "Injectable gel: Poly(ethylene glycol)-sebacic acid polyester",

abstract = "In order to develop an injectable material for drug delivery that has both formulation advantages of a sol-to-gel transition system and minimal burst release of a drug, a soft thermogel of poly(ethylene glycol)-sebacic acid polyester was synthesized. The polymer aqueous solution (25 wt%) undergoes 'clear sol-to-gel' transition as the temperature increases from 5 to 65 °C. The drug can be mixed in a low viscous sol state at low temperature (<15 °C). In particular, the thermogel is soft enough to be injected through a 21-gauge syringe needle even as a gel state. The model hydrophilic drug, FITC-dextran (molecular weight: 40,000 Da), was released from the gel over 24 h. The biodegradable poly(ethylene glycol)-sebacic acid polyester soft thermogel is believed to be promising for the hydrophilic drug delivery where an initial burst of a drug might be a concern.",

keywords = "Biodegradable polymer, Drug delivery, Sol-gel transition",

author = "Jisun Lee and Joo, {Min Kyung} and Hejin Oh and Sohn, {Youn Soo} and Byeongmoon Jeong",

note = "Funding Information: This work was supported by the Korea Research Foundation Grant (KRF-2004-005-C00090), SRC program of MOST/KOSEF through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (R11-2005-008-00000-0), and Ministry of Commerce, Industry, and Energy of Korea.",

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AU - Oh, Hejin

AU - Sohn, Youn Soo

AU - Jeong, Byeongmoon

N1 - Funding Information: This work was supported by the Korea Research Foundation Grant (KRF-2004-005-C00090), SRC program of MOST/KOSEF through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (R11-2005-008-00000-0), and Ministry of Commerce, Industry, and Energy of Korea.

PY - 2006/5/17

Y1 - 2006/5/17

N2 - In order to develop an injectable material for drug delivery that has both formulation advantages of a sol-to-gel transition system and minimal burst release of a drug, a soft thermogel of poly(ethylene glycol)-sebacic acid polyester was synthesized. The polymer aqueous solution (25 wt%) undergoes 'clear sol-to-gel' transition as the temperature increases from 5 to 65 °C. The drug can be mixed in a low viscous sol state at low temperature (<15 °C). In particular, the thermogel is soft enough to be injected through a 21-gauge syringe needle even as a gel state. The model hydrophilic drug, FITC-dextran (molecular weight: 40,000 Da), was released from the gel over 24 h. The biodegradable poly(ethylene glycol)-sebacic acid polyester soft thermogel is believed to be promising for the hydrophilic drug delivery where an initial burst of a drug might be a concern.

AB - In order to develop an injectable material for drug delivery that has both formulation advantages of a sol-to-gel transition system and minimal burst release of a drug, a soft thermogel of poly(ethylene glycol)-sebacic acid polyester was synthesized. The polymer aqueous solution (25 wt%) undergoes 'clear sol-to-gel' transition as the temperature increases from 5 to 65 °C. The drug can be mixed in a low viscous sol state at low temperature (<15 °C). In particular, the thermogel is soft enough to be injected through a 21-gauge syringe needle even as a gel state. The model hydrophilic drug, FITC-dextran (molecular weight: 40,000 Da), was released from the gel over 24 h. The biodegradable poly(ethylene glycol)-sebacic acid polyester soft thermogel is believed to be promising for the hydrophilic drug delivery where an initial burst of a drug might be a concern.

KW - Biodegradable polymer

KW - Drug delivery

KW - Sol-gel transition

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DO - 10.1016/j.polymer.2006.03.109

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SP - 3760

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JO - Polymer

JF - Polymer

IS - 11

ER -

Injectable gel: Poly(ethylene glycol)-sebacic acid polyester

Abstract

Bibliographical note

Keywords

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