Injectable gel: Poly(ethylene glycol)-sebacic acid polyester

Jisun Lee, Min Kyung Joo, Hejin Oh, Youn Soo Sohn, Byeongmoon Jeong

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


In order to develop an injectable material for drug delivery that has both formulation advantages of a sol-to-gel transition system and minimal burst release of a drug, a soft thermogel of poly(ethylene glycol)-sebacic acid polyester was synthesized. The polymer aqueous solution (25 wt%) undergoes 'clear sol-to-gel' transition as the temperature increases from 5 to 65 °C. The drug can be mixed in a low viscous sol state at low temperature (<15 °C). In particular, the thermogel is soft enough to be injected through a 21-gauge syringe needle even as a gel state. The model hydrophilic drug, FITC-dextran (molecular weight: 40,000 Da), was released from the gel over 24 h. The biodegradable poly(ethylene glycol)-sebacic acid polyester soft thermogel is believed to be promising for the hydrophilic drug delivery where an initial burst of a drug might be a concern.

Original languageEnglish
Pages (from-to)3760-3766
Number of pages7
Issue number11
StatePublished - 17 May 2006

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant (KRF-2004-005-C00090), SRC program of MOST/KOSEF through the Center for Intelligent Nano-Bio Materials at Ewha Womans University (R11-2005-008-00000-0), and Ministry of Commerce, Industry, and Energy of Korea.


  • Biodegradable polymer
  • Drug delivery
  • Sol-gel transition


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