Injectable biodegradable materials

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations

Abstract

During the last decade, there has been extensive research on injectable biodegradable materials that are to be used as an in-situ gelling depot system for sustained release of an incorporated drug. In this chapter, thermogelling biodegradable polymer aqueous solutions are reviewed. These are low-viscous sols at a low temperature and become gels at the body temperature of warm-blooded animals by heat induced sol-to-gel transition. Such a thermogelling polymer aqueous solution has been suggested to be a very promising biomaterial as a minimally invasive injectable system for drug delivery and tissue engineering applications. This chapter focuses on 'material characteristics' of the theromogelling biodegradable polymers developed so far, and 'perspectives' on the new material.

Original languageEnglish
Title of host publicationInjectable Biomaterials
Subtitle of host publicationScience and Applications
PublisherElsevier Inc.
Pages323-337
Number of pages15
ISBN (Print)9781845695880
DOIs
StatePublished - Jan 2011

Keywords

  • Biodegradability
  • Block copolymer
  • Drug delivery system
  • Hydrogel
  • In-situ gelation
  • Sol-gel transition
  • Thermosensitivity

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