Inhibitory effects of MK-801 on contextual sensitization to climbing behavior and on development of tolerance to hypothermia induced by a single high dose of apomorphine

Jae Suk Yun; Hack Seang Kim; Myung Koo Lee; Ki Wan Oh; Choon Gon Jang; Woo Kyu Park; Yeon Hee Seong; Soon Chul Lee; Sei Kwan Oh

doi:10.1006/phrs.2001.0889

Inhibitory effects of MK-801 on contextual sensitization to climbing behavior and on development of tolerance to hypothermia induced by a single high dose of apomorphine

Jae Suk Yun, Hack Seang Kim, Myung Koo Lee, Ki Wan Oh, Choon Gon Jang, Woo Kyu Park, Yeon Hee Seong, Soon Chul Lee, Sei Kwan Oh

Department of Molecular Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A single high dose of apomorphine (10 mg kg^-1) produced not only contextual sensitization to and conditioning of climbing behavior, but also context-independent tolerance to hypothermia. MK-801 (0.15 and 0.3 mg kg^-1) inhibited contextual sensitization to and conditioning of climbing behavior. Development of tolerance to hypothermia was also inhibited by MK-801. Dopamine D1 antagonist, SCH23390 (0.5 mg kg^-1), but not D2 antagonist, sulpiride, inhibited sensitization to and conditioning of climbing behavior. D2 antagonist, sulpiride (50 mg kg^-1), but not D1 antagonist, SCH23390, inhibited development of tolerance to hypothermia. These results suggest that MK-801 inhibited contextual sensitization to climbing behavior and development of tolerance to hypothermia through glutamatergic modulation of dopaminergic functions at dopamine receptors.

Original language	English
Pages (from-to)	473-479
Number of pages	7
Journal	Pharmacological Research
Volume	44
Issue number	6
DOIs	https://doi.org/10.1006/phrs.2001.0889
State	Published - 2001

Bibliographical note

Funding Information:
The authors wish to acknowledge the financial support of the Brain Korea 21 project of the Ministry of Education of the Republic of Korea.

Keywords

Apomorphine
Climbing behavior
Conditioning
Contextual sensitization
Hypothermia
MK-801
SCH23390
Sulpiride

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10.1006/phrs.2001.0889

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Yun, J. S., Kim, H. S., Lee, M. K., Oh, K. W., Jang, C. G., Park, W. K., Seong, Y. H., Lee, S. C., & Oh, S. K. (2001). Inhibitory effects of MK-801 on contextual sensitization to climbing behavior and on development of tolerance to hypothermia induced by a single high dose of apomorphine. Pharmacological Research, 44(6), 473-479. https://doi.org/10.1006/phrs.2001.0889

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title = "Inhibitory effects of MK-801 on contextual sensitization to climbing behavior and on development of tolerance to hypothermia induced by a single high dose of apomorphine",

abstract = "A single high dose of apomorphine (10 mg kg-1) produced not only contextual sensitization to and conditioning of climbing behavior, but also context-independent tolerance to hypothermia. MK-801 (0.15 and 0.3 mg kg-1) inhibited contextual sensitization to and conditioning of climbing behavior. Development of tolerance to hypothermia was also inhibited by MK-801. Dopamine D1 antagonist, SCH23390 (0.5 mg kg-1), but not D2 antagonist, sulpiride, inhibited sensitization to and conditioning of climbing behavior. D2 antagonist, sulpiride (50 mg kg-1), but not D1 antagonist, SCH23390, inhibited development of tolerance to hypothermia. These results suggest that MK-801 inhibited contextual sensitization to climbing behavior and development of tolerance to hypothermia through glutamatergic modulation of dopaminergic functions at dopamine receptors.",

keywords = "Apomorphine, Climbing behavior, Conditioning, Contextual sensitization, Hypothermia, MK-801, SCH23390, Sulpiride",

author = "Yun, {Jae Suk} and Kim, {Hack Seang} and Lee, {Myung Koo} and Oh, {Ki Wan} and Jang, {Choon Gon} and Park, {Woo Kyu} and Seong, {Yeon Hee} and Lee, {Soon Chul} and Oh, {Sei Kwan}",

note = "Funding Information: The authors wish to acknowledge the financial support of the Brain Korea 21 project of the Ministry of Education of the Republic of Korea.",

year = "2001",

doi = "10.1006/phrs.2001.0889",

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volume = "44",

pages = "473--479",

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AU - Yun, Jae Suk

AU - Kim, Hack Seang

AU - Lee, Myung Koo

AU - Oh, Ki Wan

AU - Jang, Choon Gon

AU - Park, Woo Kyu

AU - Seong, Yeon Hee

AU - Lee, Soon Chul

AU - Oh, Sei Kwan

N1 - Funding Information: The authors wish to acknowledge the financial support of the Brain Korea 21 project of the Ministry of Education of the Republic of Korea.

PY - 2001

Y1 - 2001

N2 - A single high dose of apomorphine (10 mg kg-1) produced not only contextual sensitization to and conditioning of climbing behavior, but also context-independent tolerance to hypothermia. MK-801 (0.15 and 0.3 mg kg-1) inhibited contextual sensitization to and conditioning of climbing behavior. Development of tolerance to hypothermia was also inhibited by MK-801. Dopamine D1 antagonist, SCH23390 (0.5 mg kg-1), but not D2 antagonist, sulpiride, inhibited sensitization to and conditioning of climbing behavior. D2 antagonist, sulpiride (50 mg kg-1), but not D1 antagonist, SCH23390, inhibited development of tolerance to hypothermia. These results suggest that MK-801 inhibited contextual sensitization to climbing behavior and development of tolerance to hypothermia through glutamatergic modulation of dopaminergic functions at dopamine receptors.

AB - A single high dose of apomorphine (10 mg kg-1) produced not only contextual sensitization to and conditioning of climbing behavior, but also context-independent tolerance to hypothermia. MK-801 (0.15 and 0.3 mg kg-1) inhibited contextual sensitization to and conditioning of climbing behavior. Development of tolerance to hypothermia was also inhibited by MK-801. Dopamine D1 antagonist, SCH23390 (0.5 mg kg-1), but not D2 antagonist, sulpiride, inhibited sensitization to and conditioning of climbing behavior. D2 antagonist, sulpiride (50 mg kg-1), but not D1 antagonist, SCH23390, inhibited development of tolerance to hypothermia. These results suggest that MK-801 inhibited contextual sensitization to climbing behavior and development of tolerance to hypothermia through glutamatergic modulation of dopaminergic functions at dopamine receptors.

KW - Apomorphine

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KW - Conditioning

KW - Contextual sensitization

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SN - 1043-6618

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JO - Pharmacological Research

JF - Pharmacological Research

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ER -

Inhibitory effects of MK-801 on contextual sensitization to climbing behavior and on development of tolerance to hypothermia induced by a single high dose of apomorphine

Abstract

Bibliographical note

Keywords

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