Inhibitory Effects of Furanocoumarins From the Roots of Angelica dahurica on Ionizing Radiation-Induced Migration of A549 Human Non-Small Cell Lung Cancer Cells

Sang Hoon Lee; Ah Reum Han; Unwoo Kang; Jin Baek Kim; Eun Kyoung Seo; Chan Hun Jung

doi:10.1177/1934578X20915036

Inhibitory Effects of Furanocoumarins From the Roots of Angelica dahurica on Ionizing Radiation-Induced Migration of A549 Human Non-Small Cell Lung Cancer Cells

Sang Hoon Lee, Ah Reum Han, Unwoo Kang, Jin Baek Kim, Eun Kyoung Seo, Chan Hun Jung

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Radiation therapy is a very effective tool for the treatment of advanced human lung cancers. However, as one of its malignancy-promoting behaviors, ionizing radiation (IR) increases cell migration and radiation resistance in several lung cancer cells, including non-small cell lung cancer (NSCLC) cells. As part of our ongoing search for potent radiotherapy enhancers from medicinal herbs, a chloroform-soluble fraction of the roots of Angelica dahurica was subjected to phytochemical investigation, leading to the isolation of 8 furanocoumarins. Of these, psoralen (1), xanthotoxin (2), and bergapten (3) inhibited IR-induced migration at a non-cytotoxic concentration (50 μM) in human NSCLC A549 cells. This study is the first to report on the inhibitory activities of these constituents of A. dahurica against IR-induced cancer metastasis.

Original language	English
Journal	Natural Product Communications
Volume	15
Issue number	4
DOIs	https://doi.org/10.1177/1934578X20915036
State	Published - 2020

Bibliographical note

Funding Information:
The author(s) disclose receipt of the following financial support for the research, authorship, and/or publication of this article: Grants from the National Research Foundation of Korea (No. 2017R1C1B2006273) and the Korea Atomic Energy Research Institute (KAERI).

Publisher Copyright:
© The Author(s) 2020.

Keywords

Angelica dahurica
apiaceae
furanocoumarin
non-small-cell lung cancer cells
radiation-induced migration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Inhibitory Effects of Furanocoumarins From the Roots of Angelica dahurica on Ionizing Radiation-Induced Migration of A549 Human Non-Small Cell Lung Cancer Cells",

abstract = "Radiation therapy is a very effective tool for the treatment of advanced human lung cancers. However, as one of its malignancy-promoting behaviors, ionizing radiation (IR) increases cell migration and radiation resistance in several lung cancer cells, including non-small cell lung cancer (NSCLC) cells. As part of our ongoing search for potent radiotherapy enhancers from medicinal herbs, a chloroform-soluble fraction of the roots of Angelica dahurica was subjected to phytochemical investigation, leading to the isolation of 8 furanocoumarins. Of these, psoralen (1), xanthotoxin (2), and bergapten (3) inhibited IR-induced migration at a non-cytotoxic concentration (50 μM) in human NSCLC A549 cells. This study is the first to report on the inhibitory activities of these constituents of A. dahurica against IR-induced cancer metastasis.",

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author = "Lee, {Sang Hoon} and Han, {Ah Reum} and Unwoo Kang and Kim, {Jin Baek} and Seo, {Eun Kyoung} and Jung, {Chan Hun}",

note = "Funding Information: The author(s) disclose receipt of the following financial support for the research, authorship, and/or publication of this article: Grants from the National Research Foundation of Korea (No. 2017R1C1B2006273) and the Korea Atomic Energy Research Institute (KAERI). Publisher Copyright: {\textcopyright} The Author(s) 2020.",

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doi = "10.1177/1934578X20915036",

language = "English",

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journal = "Natural Product Communications",

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AU - Lee, Sang Hoon

AU - Han, Ah Reum

AU - Kang, Unwoo

AU - Kim, Jin Baek

AU - Seo, Eun Kyoung

AU - Jung, Chan Hun

N1 - Funding Information: The author(s) disclose receipt of the following financial support for the research, authorship, and/or publication of this article: Grants from the National Research Foundation of Korea (No. 2017R1C1B2006273) and the Korea Atomic Energy Research Institute (KAERI). Publisher Copyright: © The Author(s) 2020.

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Y1 - 2020

N2 - Radiation therapy is a very effective tool for the treatment of advanced human lung cancers. However, as one of its malignancy-promoting behaviors, ionizing radiation (IR) increases cell migration and radiation resistance in several lung cancer cells, including non-small cell lung cancer (NSCLC) cells. As part of our ongoing search for potent radiotherapy enhancers from medicinal herbs, a chloroform-soluble fraction of the roots of Angelica dahurica was subjected to phytochemical investigation, leading to the isolation of 8 furanocoumarins. Of these, psoralen (1), xanthotoxin (2), and bergapten (3) inhibited IR-induced migration at a non-cytotoxic concentration (50 μM) in human NSCLC A549 cells. This study is the first to report on the inhibitory activities of these constituents of A. dahurica against IR-induced cancer metastasis.

AB - Radiation therapy is a very effective tool for the treatment of advanced human lung cancers. However, as one of its malignancy-promoting behaviors, ionizing radiation (IR) increases cell migration and radiation resistance in several lung cancer cells, including non-small cell lung cancer (NSCLC) cells. As part of our ongoing search for potent radiotherapy enhancers from medicinal herbs, a chloroform-soluble fraction of the roots of Angelica dahurica was subjected to phytochemical investigation, leading to the isolation of 8 furanocoumarins. Of these, psoralen (1), xanthotoxin (2), and bergapten (3) inhibited IR-induced migration at a non-cytotoxic concentration (50 μM) in human NSCLC A549 cells. This study is the first to report on the inhibitory activities of these constituents of A. dahurica against IR-induced cancer metastasis.

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Inhibitory Effects of Furanocoumarins From the Roots of Angelica dahurica on Ionizing Radiation-Induced Migration of A549 Human Non-Small Cell Lung Cancer Cells

Abstract

Bibliographical note

Keywords

UN SDGs

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