Inhibitory effects of biochanin A on mouse lung tumor induced by benzo(a)pyrene.

Y. S. Lee, J. S. Seo, H. T. Chung, J. J. Jang

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Abstract

Biochanin A, an isoflavone compound, is reported to have an inhibitory effect on benzo(a)pyrene [B(a)P] metabolism. We examined the modifying effect of biochanin A on in vivo carcinogenesis using a mouse lung tumor model. As carcinogens, a single subcutaneous injection of 0.5mg of B(a)P was given within 24 hours after birth. The test groups were injected with 0.125mg of biochanin A in 0.1ml DMSO by i.p. 3 times a week for 6 weeks after weaning. All mice were sacrificed at week 9 and the incidence and multiplicity of lung tumors were examined. Concomitant administration of biochanin A showed a significant inhibitory effect on the incidence of tumor-bearing mice (12.5%, P < 0.01), as well as the mean number of tumors (0.13, P < 0.001), compared with the group treated with B(a)P alone in which the incidence was 57.1% and the mean number was 1.0. These results suggest that biochanin A has inhibitory potential on the development of mouse lung tumor induced by B(a)P.

Original languageEnglish
Pages (from-to)325-328
Number of pages4
JournalJournal of Korean Medical Science
Volume6
Issue number4
DOIs
StatePublished - Dec 1991

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