Inhibition of STAT6 Activation by AS1517499 Inhibits Expression and Activity of PPARγ in Macrophages to Resolve Acute Inflammation in Mice

Medicine & Life Sciences

• 4-(benzylamino)-2-((2-(3-chloro-4-hydroxyphenyl)ethyl)amino)pyrimidine-5-carboxamide 100%
• STAT6 Transcription Factor 71%
• Peroxisome Proliferator-Activated Receptors 54%
• Transcriptional Activation 41%
• Macrophages 31%
• Peritoneal Macrophages 28%
• Inflammation 26%
• Peritoneal Lavage 26%
• Ascitic Fluid 22%
• Zymosan 16%
• Annexin A1 9%
• Anti-Inflammatory Agents 9%
• Annexins 8%
• Cytokines 8%
• Macrophage Activation 7%
• Peritonitis 6%
• Neutrophils 5%
• Spleen 5%
• Proteins 4%
• Homeostasis 4%
• Phosphorylation 4%
• Injections 3%
• Messenger RNA 3%
• In Vitro Techniques 2%

Chemical Compounds

• Peritoneal Dialysis Fluid 85%
• Antiinflammatory 29%
• Protein 12%