Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of Agastache rugosa

Jung Joo Hong; Jae Hoon Choi; Sei Ryang Oh; Hyeong Kyu Lee; Jae Hak Park; Kun Yeong Lee; Jung Jae Kim; Tae Sook Jeong; Goo Taeg Oh

doi:10.1016/S0014-5793(01)02379-1

Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of Agastache rugosa

Jung Joo Hong
, Jae Hoon Choi
, Sei Ryang Oh
, Hyeong Kyu Lee
, Jae Hak Park
, Kun Yeong Lee
, Jung Jae Kim
, Tae Sook Jeong
, Goo Taeg Oh

Department of Life Science

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptor -/- mice. Moreover, A. rugosa reduced macrophage infiltration and VCAM-1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that tilianin (100 μM), a major component of A. rugosa, inhibits the tumor necrotic factor-α (TNF-α)-induced expression of VCAM-1 by 74% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 μM) reduced TNF-α-induced activation of nuclear factor-κB in HUVECs.

Original language	English
Pages (from-to)	142-147
Number of pages	6
Journal	FEBS Letters
Volume	495
Issue number	3
DOIs	https://doi.org/10.1016/S0014-5793(01)02379-1
State	Published - 27 Apr 2001

Bibliographical note

Funding Information:
We wish to thank Dr. Nobuyo Maeda (UNC-Chapel Hill, NC, USA) for helpful comments and suggestions, Ju-Ryoung Kim for FPLC analysis, Myoung-Soo Kim, Seong-Kyu Kim for their technical assistance, and Philip McElroy for the English revision. This work was financially supported by the Molecular Medicine Research Group Program (99-J03-01-01-A-05) from MOST and the SGRP/HTD Program (298045-3) from ARPC, Korea.

Keywords

Agastache rugosa
Atherosclerosis
Macrophage
Nuclear factor-κB
Tilianin
Vascular cell adhesion molecule-1

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10.1016/S0014-5793(01)02379-1

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title = "Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of Agastache rugosa",

abstract = "Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptor -/- mice. Moreover, A. rugosa reduced macrophage infiltration and VCAM-1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that tilianin (100 μM), a major component of A. rugosa, inhibits the tumor necrotic factor-α (TNF-α)-induced expression of VCAM-1 by 74\% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 μM) reduced TNF-α-induced activation of nuclear factor-κB in HUVECs.",

keywords = "Agastache rugosa, Atherosclerosis, Macrophage, Nuclear factor-κB, Tilianin, Vascular cell adhesion molecule-1",

author = "Hong, \{Jung Joo\} and Choi, \{Jae Hoon\} and Oh, \{Sei Ryang\} and Lee, \{Hyeong Kyu\} and Park, \{Jae Hak\} and Lee, \{Kun Yeong\} and Kim, \{Jung Jae\} and Jeong, \{Tae Sook\} and Oh, \{Goo Taeg\}",

note = "Funding Information: We wish to thank Dr. Nobuyo Maeda (UNC-Chapel Hill, NC, USA) for helpful comments and suggestions, Ju-Ryoung Kim for FPLC analysis, Myoung-Soo Kim, Seong-Kyu Kim for their technical assistance, and Philip McElroy for the English revision. This work was financially supported by the Molecular Medicine Research Group Program (99-J03-01-01-A-05) from MOST and the SGRP/HTD Program (298045-3) from ARPC, Korea.",

year = "2001",

month = apr,

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doi = "10.1016/S0014-5793(01)02379-1",

language = "English",

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pages = "142--147",

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AU - Hong, Jung Joo

AU - Choi, Jae Hoon

AU - Oh, Sei Ryang

AU - Lee, Hyeong Kyu

AU - Park, Jae Hak

AU - Lee, Kun Yeong

AU - Kim, Jung Jae

AU - Jeong, Tae Sook

AU - Oh, Goo Taeg

N1 - Funding Information: We wish to thank Dr. Nobuyo Maeda (UNC-Chapel Hill, NC, USA) for helpful comments and suggestions, Ju-Ryoung Kim for FPLC analysis, Myoung-Soo Kim, Seong-Kyu Kim for their technical assistance, and Philip McElroy for the English revision. This work was financially supported by the Molecular Medicine Research Group Program (99-J03-01-01-A-05) from MOST and the SGRP/HTD Program (298045-3) from ARPC, Korea.

PY - 2001/4/27

Y1 - 2001/4/27

N2 - Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptor -/- mice. Moreover, A. rugosa reduced macrophage infiltration and VCAM-1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that tilianin (100 μM), a major component of A. rugosa, inhibits the tumor necrotic factor-α (TNF-α)-induced expression of VCAM-1 by 74% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 μM) reduced TNF-α-induced activation of nuclear factor-κB in HUVECs.

AB - Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptor -/- mice. Moreover, A. rugosa reduced macrophage infiltration and VCAM-1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that tilianin (100 μM), a major component of A. rugosa, inhibits the tumor necrotic factor-α (TNF-α)-induced expression of VCAM-1 by 74% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 μM) reduced TNF-α-induced activation of nuclear factor-κB in HUVECs.

KW - Agastache rugosa

KW - Atherosclerosis

KW - Macrophage

KW - Nuclear factor-κB

KW - Tilianin

KW - Vascular cell adhesion molecule-1

UR - https://www.scopus.com/pages/publications/0035957698

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DO - 10.1016/S0014-5793(01)02379-1

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AN - SCOPUS:0035957698

SN - 0014-5793

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JO - FEBS Letters

JF - FEBS Letters

IS - 3

ER -

Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of Agastache rugosa

Abstract

Bibliographical note

Keywords

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