Abstract
Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptor -/- mice. Moreover, A. rugosa reduced macrophage infiltration and VCAM-1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that tilianin (100 μM), a major component of A. rugosa, inhibits the tumor necrotic factor-α (TNF-α)-induced expression of VCAM-1 by 74% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 μM) reduced TNF-α-induced activation of nuclear factor-κB in HUVECs.
Original language | English |
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Pages (from-to) | 142-147 |
Number of pages | 6 |
Journal | FEBS Letters |
Volume | 495 |
Issue number | 3 |
DOIs | |
State | Published - 27 Apr 2001 |
Keywords
- Agastache rugosa
- Atherosclerosis
- Macrophage
- Nuclear factor-κB
- Tilianin
- Vascular cell adhesion molecule-1