Inhibition of African swine fever virus protease by myricetin and myricitrin

Seri Jo, Suwon Kim, Dong Hae Shin, Mi Sun Kim

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

African swine fever (ASF) caused by the ASF virus (ASFV) is the most hazardous swine disease. Since a huge number of pigs have been slaughtered to avoid a pandemic spread, intense studies on the disease should be followed quickly. Recent studies reported that flavonoids have various antiviral activity including ASFV. In this report, ASFV protease was selected as an antiviral target protein to cope with ASF. With a FRET (Fluorescence resonance energy transfer) method, ASFV protease was assayed with a flavonoid library which was composed of sixty-five derivatives classified based on ten different scaffolds. Of these, the flavonols scaffold contains a potential anti-ASFV protease activity. The most prominent flavonol was myricetin with IC50 of 8.4 μM. Its derivative, myricitrin, with the rhamnoside moiety was also showed the profound inhibitory effect on ASFV protease. These two flavonols apparently provide a way to develop anti-ASFV agents based on their scaffold.

Original languageEnglish
Pages (from-to)1045-1049
Number of pages5
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume35
Issue number1
DOIs
StatePublished - 1 Jan 2020

Keywords

  • African swine fever virus protease
  • antiviral
  • flavonoid
  • fret
  • inhibitory compounds

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