Inhibition by MK-801 of cocaine-induced sensitization, conditioned place preference, and dopamine-receptor supersensitivity in mice

Hack Seang Kim, Woo Kyu Park, Choon Gon Jang, Seikwan Oh

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Repeated administration of cocaine led to increases in ambulation- accelerating activity (sensitization) and conditioned place preference (CPP). Dopamine (DA)-receptor supersensitivity was also developed in cocaine- induced sensitized and CPP mice. An N-methyl-D-aspartate (NMDA)-receptor antagonist, MK-801, blocked simultaneously developments of cocaine-induced behavioral sensitization, CPP, and DA-receptor supersensitivity. Furthermore, MK-801 inhibited a apomorphine-induced striatal dopaminergic action: climbing behavior. These results suggest that the cocaine-induced dopaminergic behaviors such as sensitization to ambulatory activity and CPP may be produced via activation of the NMDA receptor. The development of postsynaptic DA-receptor supersensitivity may be an underlying common mechanism that mediates cocaine-induced behavioral sensitization and CPP.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalBrain Research Bulletin
Volume40
Issue number3
DOIs
StatePublished - 1996

Keywords

  • Behavioral sensitization
  • Cocaine
  • Dopamine-receptor supersensitivity
  • MK-801
  • Place conditioning

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