Abstract
Repeated administration of cocaine led to increases in ambulation- accelerating activity (sensitization) and conditioned place preference (CPP). Dopamine (DA)-receptor supersensitivity was also developed in cocaine- induced sensitized and CPP mice. An N-methyl-D-aspartate (NMDA)-receptor antagonist, MK-801, blocked simultaneously developments of cocaine-induced behavioral sensitization, CPP, and DA-receptor supersensitivity. Furthermore, MK-801 inhibited a apomorphine-induced striatal dopaminergic action: climbing behavior. These results suggest that the cocaine-induced dopaminergic behaviors such as sensitization to ambulatory activity and CPP may be produced via activation of the NMDA receptor. The development of postsynaptic DA-receptor supersensitivity may be an underlying common mechanism that mediates cocaine-induced behavioral sensitization and CPP.
Original language | English |
---|---|
Pages (from-to) | 201-207 |
Number of pages | 7 |
Journal | Brain Research Bulletin |
Volume | 40 |
Issue number | 3 |
DOIs | |
State | Published - 1996 |
Keywords
- Behavioral sensitization
- Cocaine
- Dopamine-receptor supersensitivity
- MK-801
- Place conditioning