Inhibition by ginsenosides Rb1 and Rg1 of methamphetamine-induced hyperactivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice

Hack Seang Kim; Youn Tack Hong; Ki Wan Oh; Youn Hee Seong; Hang Mook Rheu; Dae Hyun Cho; Seikwan Oh; Woo Kyu Park; Choon Gon Jang

doi:10.1016/S0306-3623(97)00330-3

Inhibition by ginsenosides Rb₁ and Rg₁ of methamphetamine-induced hyperactivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice

Hack Seang Kim, Youn Tack Hong, Ki Wan Oh, Youn Hee Seong, Hang Mook Rheu, Dae Hyun Cho, Seikwan Oh, Woo Kyu Park, Choon Gon Jang

Department of Molecular Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The ginsenosides Rb₁ and Rg₁, the major components of ginseng saponin, inhibited not only methamphetamine induced hyperactivity but also conditioned place preference (CPP) in mice following a single or repeated administration. Dopamine (DA) receptor supersensitivity, which developed in methamphetamine induced CPP mice, was also inhibited by both Rb₁ and Rg₁. Therefore, the present results suggest that Rb₁ and Rg₁ may be the active components of ginseng saponin in the modulation of methamphetamine induced dopaminergic behaviors such as hyperactivity and CPP, supporting our previous conclusion that ginseng saponin might modulate methamphetamine induced dysfunction at both the pre- and postsynaptic DA receptors.

Original language	English
Pages (from-to)	783-789
Number of pages	7
Journal	General Pharmacology
Volume	30
Issue number	5
DOIs	https://doi.org/10.1016/S0306-3623(97)00330-3
State	Published - May 1998

Bibliographical note

Funding Information:
This study was supported by a grant (1996–97) from the Research Center for New Drug Development, College of Pharmacy, Seoul National University, Republic of Korea.

Keywords

Conditioned place preference
Dopamine receptor supersensitivity
Ginsenoside
Hyperactivity
Methamphetamine
Panax ginseng

Access to Document

10.1016/S0306-3623(97)00330-3

Cite this

Kim, H. S., Hong, Y. T., Oh, K. W., Seong, Y. H., Rheu, H. M., Cho, D. H., Oh, S., Park, W. K., & Jang, C. G. (1998). Inhibition by ginsenosides Rb₁ and Rg₁ of methamphetamine-induced hyperactivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice. General Pharmacology, 30(5), 783-789. https://doi.org/10.1016/S0306-3623(97)00330-3

@article{27833f0aad90455e9943f99fb64b6e27,

title = "Inhibition by ginsenosides Rb1 and Rg1 of methamphetamine-induced hyperactivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice",

abstract = "The ginsenosides Rb1 and Rg1, the major components of ginseng saponin, inhibited not only methamphetamine induced hyperactivity but also conditioned place preference (CPP) in mice following a single or repeated administration. Dopamine (DA) receptor supersensitivity, which developed in methamphetamine induced CPP mice, was also inhibited by both Rb1 and Rg1. Therefore, the present results suggest that Rb1 and Rg1 may be the active components of ginseng saponin in the modulation of methamphetamine induced dopaminergic behaviors such as hyperactivity and CPP, supporting our previous conclusion that ginseng saponin might modulate methamphetamine induced dysfunction at both the pre- and postsynaptic DA receptors.",

keywords = "Conditioned place preference, Dopamine receptor supersensitivity, Ginsenoside, Hyperactivity, Methamphetamine, Panax ginseng",

author = "Kim, {Hack Seang} and Hong, {Youn Tack} and Oh, {Ki Wan} and Seong, {Youn Hee} and Rheu, {Hang Mook} and Cho, {Dae Hyun} and Seikwan Oh and Park, {Woo Kyu} and Jang, {Choon Gon}",

note = "Funding Information: This study was supported by a grant (1996–97) from the Research Center for New Drug Development, College of Pharmacy, Seoul National University, Republic of Korea.",

year = "1998",

month = may,

doi = "10.1016/S0306-3623(97)00330-3",

language = "English",

volume = "30",

pages = "783--789",

journal = "General Pharmacology",

issn = "0306-3623",

publisher = "Elsevier BV",

number = "5",

}

TY - JOUR

T1 - Inhibition by ginsenosides Rb1 and Rg1 of methamphetamine-induced hyperactivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice

AU - Kim, Hack Seang

AU - Hong, Youn Tack

AU - Oh, Ki Wan

AU - Seong, Youn Hee

AU - Rheu, Hang Mook

AU - Cho, Dae Hyun

AU - Oh, Seikwan

AU - Park, Woo Kyu

AU - Jang, Choon Gon

N1 - Funding Information: This study was supported by a grant (1996–97) from the Research Center for New Drug Development, College of Pharmacy, Seoul National University, Republic of Korea.

PY - 1998/5

Y1 - 1998/5

N2 - The ginsenosides Rb1 and Rg1, the major components of ginseng saponin, inhibited not only methamphetamine induced hyperactivity but also conditioned place preference (CPP) in mice following a single or repeated administration. Dopamine (DA) receptor supersensitivity, which developed in methamphetamine induced CPP mice, was also inhibited by both Rb1 and Rg1. Therefore, the present results suggest that Rb1 and Rg1 may be the active components of ginseng saponin in the modulation of methamphetamine induced dopaminergic behaviors such as hyperactivity and CPP, supporting our previous conclusion that ginseng saponin might modulate methamphetamine induced dysfunction at both the pre- and postsynaptic DA receptors.

AB - The ginsenosides Rb1 and Rg1, the major components of ginseng saponin, inhibited not only methamphetamine induced hyperactivity but also conditioned place preference (CPP) in mice following a single or repeated administration. Dopamine (DA) receptor supersensitivity, which developed in methamphetamine induced CPP mice, was also inhibited by both Rb1 and Rg1. Therefore, the present results suggest that Rb1 and Rg1 may be the active components of ginseng saponin in the modulation of methamphetamine induced dopaminergic behaviors such as hyperactivity and CPP, supporting our previous conclusion that ginseng saponin might modulate methamphetamine induced dysfunction at both the pre- and postsynaptic DA receptors.

KW - Conditioned place preference

KW - Dopamine receptor supersensitivity

KW - Ginsenoside

KW - Hyperactivity

KW - Methamphetamine

KW - Panax ginseng

UR - http://www.scopus.com/inward/record.url?scp=0031596648&partnerID=8YFLogxK

U2 - 10.1016/S0306-3623(97)00330-3

DO - 10.1016/S0306-3623(97)00330-3

M3 - Article

C2 - 9559335

AN - SCOPUS:0031596648

SN - 0306-3623

VL - 30

SP - 783

EP - 789

JO - General Pharmacology

JF - General Pharmacology

IS - 5

ER -