The ginsenosides Rb1 and Rg1, the major components of ginseng saponin, inhibited not only methamphetamine induced hyperactivity but also conditioned place preference (CPP) in mice following a single or repeated administration. Dopamine (DA) receptor supersensitivity, which developed in methamphetamine induced CPP mice, was also inhibited by both Rb1 and Rg1. Therefore, the present results suggest that Rb1 and Rg1 may be the active components of ginseng saponin in the modulation of methamphetamine induced dopaminergic behaviors such as hyperactivity and CPP, supporting our previous conclusion that ginseng saponin might modulate methamphetamine induced dysfunction at both the pre- and postsynaptic DA receptors.
Bibliographical noteFunding Information:
This study was supported by a grant (1996–97) from the Research Center for New Drug Development, College of Pharmacy, Seoul National University, Republic of Korea.
- Conditioned place preference
- Dopamine receptor supersensitivity
- Panax ginseng