Inhibition by ginsenosides Rb1 and Rg1 of methamphetamine-induced hyperactivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice

Hack Seang Kim, Youn Tack Hong, Ki Wan Oh, Youn Hee Seong, Hang Mook Rheu, Dae Hyun Cho, Seikwan Oh, Woo Kyu Park, Choon Gon Jang

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24 Scopus citations

Abstract

The ginsenosides Rb1 and Rg1, the major components of ginseng saponin, inhibited not only methamphetamine induced hyperactivity but also conditioned place preference (CPP) in mice following a single or repeated administration. Dopamine (DA) receptor supersensitivity, which developed in methamphetamine induced CPP mice, was also inhibited by both Rb1 and Rg1. Therefore, the present results suggest that Rb1 and Rg1 may be the active components of ginseng saponin in the modulation of methamphetamine induced dopaminergic behaviors such as hyperactivity and CPP, supporting our previous conclusion that ginseng saponin might modulate methamphetamine induced dysfunction at both the pre- and postsynaptic DA receptors.

Original languageEnglish
Pages (from-to)783-789
Number of pages7
JournalGeneral Pharmacology
Volume30
Issue number5
DOIs
StatePublished - May 1998

Keywords

  • Conditioned place preference
  • Dopamine receptor supersensitivity
  • Ginsenoside
  • Hyperactivity
  • Methamphetamine
  • Panax ginseng

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