Influence of the CYP3A5 and MDR1 genetic polymorphisms on the pharmacokinetics of tacrolimus in healthy Korean subjects

Ji H. Choi, Yoon J. Lee, Seong B. Jang, Jong Eun Lee, Kyung H. Kim, Kyungsoo Park

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Aims: To determine the frequencies of the genotypes of CYP3A5 and MDR1 and to examine the influence of the polymorphisms of these genes on tacrolimus pharmacokinetics in the Korean population. Methods: Twenty-nine healthy Koreans who participated in the previous tacrolimus pharmacokinetic study were genotyped for CYP3A4*1B, CYP3A5*3, MDR1 c.1236C→T, MDR1 c.2677G→A/T and MDR1 c.3435C→T. The relationship between the genotypes so obtained and tacrolimus pharmacokinetics observed in the previous study was examined. Results: No subject in this study had the CYP3A4*1B variant. The observed frequencies of CYP3A5*1/*1, *1/*3, and *3/*3 were 0.069 [confidence interval (CI) -0.023, 0.161], 0.483 (CI 0.301, 0.665) and 0.448 (CI 0.267, 0.629), respectively. AUC0-∞ for the CYP3A5*1/*1 or *1/*3 genotype was 131.5 ± 44.8 ng h ml-1 (CI 109.6, 153.5), which was much lower compared with the CYP3A5*3/*3 genotype of 323.8 ± 129.3 ng h ml-1 (CI 253.5, 394.1) (P = 2.063E-07). Similarly, Cmax for the CYP3A5*1/*1 or *1/*3 genotype was 11.8 ± 3.4 ng ml-1 (CI 10.1, 13.5), which was also much lower compared with the CYP3A5*3/*3 genotype of 24.4 ± 12.3 ng ml-1 (CI 17.8, 31.1) (P = 0.0001). However, there was no significant difference in tacrolimus pharmacokinetics among the MDR1 diplotypes of CGC-CGC, CGC-TTT, CGC-TGC, TTT-TGC or TTT-TTT (P = 0.2486). Conclusions This study shows that the CYP3A5*3 genetic polymorphisms may be associated with the individual difference in tacrolimus pharmacokinetics. An individualized dosage regimen design incorporating such genetic information would help increase clinical efficacy of the drug while reducing adverse drug reactions.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalBritish Journal of Clinical Pharmacology
Volume64
Issue number2
DOIs
StatePublished - Aug 2007

Keywords

  • CYP3A5
  • MDR1
  • Pharmacokinetics
  • Polymorphism
  • Tacrolimus

Fingerprint

Dive into the research topics of 'Influence of the CYP3A5 and MDR1 genetic polymorphisms on the pharmacokinetics of tacrolimus in healthy Korean subjects'. Together they form a unique fingerprint.

Cite this