Abstract
Aim: L-benzyl-3-cetyl-2-methylimidazolium iodide (NH125) can inhibit Staphylococcus aureus growth. We investigated the effects of sub-MIC concentrations of NH125 on S. aureus biofilm and virulence. Methodology & results: Three strains of S. aureus were tested. Sub-lethal concentrations of NH125 repressed biofilm formation. At partial sub-MICs, NH125 downregulated the expression of most virulence, while strain-dependent effects were found in the production of α-hemolysin, δ-hemolysin, coagulase and nuclease. In Galleria mellonella model, methicillin-resistant S. aureus pre-exposed to NH125 demonstrated significantly lower killing (p = 0.032 for 1/16 and 1/8 MICs; 0.008 for 1/4 MIC; and 0.001 for 1/2 MIC). Conclusion: Sub-MIC concentrations of NH125 inhibited biofilm formation and virulence of S. aureus. These findings provide further support for evaluating the clinical efficacy of NH125 in staphylococcal infection.
| Original language | English |
|---|---|
| Pages (from-to) | 1319-1331 |
| Number of pages | 13 |
| Journal | Future Medicinal Chemistry |
| Volume | 10 |
| Issue number | 11 |
| DOIs | |
| State | Published - Jun 2018 |
Bibliographical note
Publisher Copyright:© 2018 Newlands Press.
Keywords
- NH125
- Staphylococcus aureus
- sub-MIC
- virulence factor