Induction of apoptosis by ginseng saponin metabolite in U937 human monocytic leukemia cells

Kyoung Ah Kang, Hee Kyoung Lim, Seung Uk Kim, Yeong Wan Kim, Won Taek Kim, Ha Sook Chung, Min Kyung Choo, Dong Hyun Kim, Hee Sun Kim, Mi Ja Shim, Myung Hee Chung, Jin Won Hyun

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We report the cytotoxicity of the ginseng saponin metabolite, Compound K (20-0-D-glucopyranosyl-20(S)-protopanaxadiol, 1H901) on various human leukemia cell lines. Compound K had the most effect on U937, a human monocytic leukemia cell line among the tested cell lines. Compound K-treated U937 cells showed characteristics of apoptosis: an exposure of phosphatidylserine from the inner cell membrane to the outer cell membrane, the formation of apoptotic bodies and DNA fragmentation. Compound K induced apoptosis by up-regulating Box, disrupting the mitochondrial membrane potential, and by activating caspase 9 and caspase 3. Therefore, we suggest that Compound K inhibits U937 cell growth by inducing apoptosis through the up-regulation of Bax and caspase activation.

Original languageEnglish
Pages (from-to)27-40
Number of pages14
JournalJournal of Food Biochemistry
Volume29
Issue number1
DOIs
StatePublished - Feb 2005

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