@inproceedings{5710857fbcc947b29af22fbd837ead33,
title = "Inducing cellular alignment on micropost arrays via biophysical spatial stimuli",
abstract = "Micropost arrays are widely used to quantify cellular traction forces on the substrate; however, the ability to control cell morphology on micropost arrays has remained a challenge. Here we present a biophysical method for inducing cellular alignment on micropost arrays. Experimental results for bovine aortic endothelial cells (BAECs) revealed that comparatively higher interpost spacing along one axis significantly promoted cellular alignment along the perpendicular axis. By the end of 18-hour studies, BAECs were aligned within 26°±4° (n = 39 cells) of the designated axis on average, with 36% of seeded BAECs aligned within 10° of the designated axis. Thus, this methodology could be readily employed to simultaneously achieve both cellular alignment and traction force quantification.",
keywords = "Biophysics, Cell alignment, Micropillars, Microposts",
author = "Sochol, {Ryan D.} and Chang, {Sheng Chih} and Higa, {Adrienne T.} and Dueck, {Megan E.} and Lee, {Luke P.} and Song Li and Liwei Lin",
year = "2011",
language = "English",
isbn = "9781618395955",
series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
pages = "813--815",
booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
note = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",
}