Increased risk of postoperative complications after total thyroidectomy with Graves' disease

Hyungju Kwon, Jong kyu Kim, Woosung Lim, Byung In Moon, Nam Sun Paik

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background: The effect of Graves' disease on the risk of postoperative complications in patients undergoing total thyroidectomy is unclear. Methods: The incidence of recurrent laryngeal nerve (RLN) injury and hypoparathyroidism were analyzed between 165 patients with Graves' disease (GD group) and 1:1 matched patients with euthyroid states (control group). Results: The matched cohorts did not differ in age, sex, body mass index, pathologic diagnosis, and extent of operation. Excised thyroid weight was higher in the Graves' disease than in the control group (60.1 g vs 22.6 g; P <.001). Multivariate analysis showed that Graves' disease significantly increased risks of transient RLN injury (odds ratio [OR] = 4.7, 95% confidence interval [CI] = 1.5-15.5; P =.010) and transient hypoparathyroidism (OR = 2.8, 95% CI = 1.3-5.8; P =.007). Rates of permanent complications were comparable in the Graves' disease and control groups. Conclusions: Graves' disease can be a predictive factor for postoperative RLN injury and hypoparathyroidism after total thyroidectomy.

Original languageEnglish
Pages (from-to)281-285
Number of pages5
JournalHead and Neck
Issue number2
StatePublished - Feb 2019

Bibliographical note

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.


  • Graves' disease
  • RLN injury
  • complications
  • hypoparathyroidism
  • thyroidectomy


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