Increased risk of postoperative complications after total thyroidectomy with Graves' disease

Hyungju Kwon; Jong kyu Kim; Woosung Lim; Byung In Moon; Nam Sun Paik

doi:10.1002/hed.25484

Increased risk of postoperative complications after total thyroidectomy with Graves' disease

Hyungju Kwon, Jong kyu Kim, Woosung Lim, Byung In Moon, Nam Sun Paik

Department of Surgery

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: The effect of Graves' disease on the risk of postoperative complications in patients undergoing total thyroidectomy is unclear. Methods: The incidence of recurrent laryngeal nerve (RLN) injury and hypoparathyroidism were analyzed between 165 patients with Graves' disease (GD group) and 1:1 matched patients with euthyroid states (control group). Results: The matched cohorts did not differ in age, sex, body mass index, pathologic diagnosis, and extent of operation. Excised thyroid weight was higher in the Graves' disease than in the control group (60.1 g vs 22.6 g; P <.001). Multivariate analysis showed that Graves' disease significantly increased risks of transient RLN injury (odds ratio [OR] = 4.7, 95% confidence interval [CI] = 1.5-15.5; P =.010) and transient hypoparathyroidism (OR = 2.8, 95% CI = 1.3-5.8; P =.007). Rates of permanent complications were comparable in the Graves' disease and control groups. Conclusions: Graves' disease can be a predictive factor for postoperative RLN injury and hypoparathyroidism after total thyroidectomy.

Original language	English
Pages (from-to)	281-285
Number of pages	5
Journal	Head and Neck
Volume	41
Issue number	2
DOIs	https://doi.org/10.1002/hed.25484
State	Published - Feb 2019

Keywords

Graves' disease
RLN injury
complications
hypoparathyroidism
thyroidectomy

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10.1002/hed.25484

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@article{9f414fe4aae44e0490b22fe123f92ebc,

title = "Increased risk of postoperative complications after total thyroidectomy with Graves' disease",

abstract = "Background: The effect of Graves' disease on the risk of postoperative complications in patients undergoing total thyroidectomy is unclear. Methods: The incidence of recurrent laryngeal nerve (RLN) injury and hypoparathyroidism were analyzed between 165 patients with Graves' disease (GD group) and 1:1 matched patients with euthyroid states (control group). Results: The matched cohorts did not differ in age, sex, body mass index, pathologic diagnosis, and extent of operation. Excised thyroid weight was higher in the Graves' disease than in the control group (60.1 g vs 22.6 g; P <.001). Multivariate analysis showed that Graves' disease significantly increased risks of transient RLN injury (odds ratio [OR] = 4.7, 95% confidence interval [CI] = 1.5-15.5; P =.010) and transient hypoparathyroidism (OR = 2.8, 95% CI = 1.3-5.8; P =.007). Rates of permanent complications were comparable in the Graves' disease and control groups. Conclusions: Graves' disease can be a predictive factor for postoperative RLN injury and hypoparathyroidism after total thyroidectomy.",

keywords = "Graves' disease, RLN injury, complications, hypoparathyroidism, thyroidectomy",

author = "Hyungju Kwon and Kim, {Jong kyu} and Woosung Lim and Moon, {Byung In} and Paik, {Nam Sun}",

note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science & ICT (2017R1C1B5076977) Funding Information: information Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science & ICT, Grant/Award Number: 2017R1C1B5076977; Ministry of Science & ICT, Grant/Award Number: 2017R1C1B5076977This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science & ICT (2017R1C1B5076977) Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2019",

month = feb,

doi = "10.1002/hed.25484",

language = "English",

volume = "41",

pages = "281--285",

journal = "Head and Neck",

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publisher = "John Wiley & Sons Inc.",

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T1 - Increased risk of postoperative complications after total thyroidectomy with Graves' disease

AU - Kwon, Hyungju

AU - Kim, Jong kyu

AU - Lim, Woosung

AU - Moon, Byung In

AU - Paik, Nam Sun

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science & ICT (2017R1C1B5076977) Funding Information: information Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science & ICT, Grant/Award Number: 2017R1C1B5076977; Ministry of Science & ICT, Grant/Award Number: 2017R1C1B5076977This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science & ICT (2017R1C1B5076977) Publisher Copyright: © 2018 Wiley Periodicals, Inc.

PY - 2019/2

Y1 - 2019/2

N2 - Background: The effect of Graves' disease on the risk of postoperative complications in patients undergoing total thyroidectomy is unclear. Methods: The incidence of recurrent laryngeal nerve (RLN) injury and hypoparathyroidism were analyzed between 165 patients with Graves' disease (GD group) and 1:1 matched patients with euthyroid states (control group). Results: The matched cohorts did not differ in age, sex, body mass index, pathologic diagnosis, and extent of operation. Excised thyroid weight was higher in the Graves' disease than in the control group (60.1 g vs 22.6 g; P <.001). Multivariate analysis showed that Graves' disease significantly increased risks of transient RLN injury (odds ratio [OR] = 4.7, 95% confidence interval [CI] = 1.5-15.5; P =.010) and transient hypoparathyroidism (OR = 2.8, 95% CI = 1.3-5.8; P =.007). Rates of permanent complications were comparable in the Graves' disease and control groups. Conclusions: Graves' disease can be a predictive factor for postoperative RLN injury and hypoparathyroidism after total thyroidectomy.

AB - Background: The effect of Graves' disease on the risk of postoperative complications in patients undergoing total thyroidectomy is unclear. Methods: The incidence of recurrent laryngeal nerve (RLN) injury and hypoparathyroidism were analyzed between 165 patients with Graves' disease (GD group) and 1:1 matched patients with euthyroid states (control group). Results: The matched cohorts did not differ in age, sex, body mass index, pathologic diagnosis, and extent of operation. Excised thyroid weight was higher in the Graves' disease than in the control group (60.1 g vs 22.6 g; P <.001). Multivariate analysis showed that Graves' disease significantly increased risks of transient RLN injury (odds ratio [OR] = 4.7, 95% confidence interval [CI] = 1.5-15.5; P =.010) and transient hypoparathyroidism (OR = 2.8, 95% CI = 1.3-5.8; P =.007). Rates of permanent complications were comparable in the Graves' disease and control groups. Conclusions: Graves' disease can be a predictive factor for postoperative RLN injury and hypoparathyroidism after total thyroidectomy.

KW - Graves' disease

KW - RLN injury

KW - complications

KW - hypoparathyroidism

KW - thyroidectomy

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SP - 281

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JO - Head and Neck

JF - Head and Neck

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ER -

Increased risk of postoperative complications after total thyroidectomy with Graves' disease

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