TY - JOUR
T1 - Incidence, mortality, and cardiovascular diseases in pituitary adenoma in Korea
T2 - a nationwide population-based study
AU - Oh, Jae Sang
AU - Kim, Hyun Jung
AU - Hann, Hoo Jae
AU - Kang, Tae Uk
AU - Kim, Dong Sook
AU - Kang, Min Ji
AU - Lee, Ji Young
AU - Shim, Jai Joon
AU - Lee, Man Ryul
AU - Ahn, Hyeong Sik
N1 - Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/2
Y1 - 2021/2
N2 - Purpose: Few nationally representative studies have evaluated the epidemiology of PA (pituitary adenoma). This South Korean study evaluated the incidence of different PA subtypes, cardiovascular disease (CVD), and related mortality. Methods: This population-based study evaluated 31,898 patients with PA during 2005–2015. The incidence of PA, mortality, and CVD occurrence in PA cases were evaluated during a median follow-up of 5.3 years (range: 0–10 years). Cox regression analysis was used to evaluate the associations between CVD and mortality. Results: The annual incidences (per 100,000 population) were 3.5 for non-functioning pituitary adenoma (NFPA), 1.6 for prolactinoma (PRL), 0.5 for growth hormone-secreting pituitary adenoma (GH), and 0.2 for adrenocorticotropic or thyroid-stimulating hormone-secreting pituitary adenoma (ACTH + TSH). The standardized mortality ratios were 1.9 for ACTH + TSH, 1.7 for NFPA with hypopituitarism, 1.4 for NFPA without hypopituitarism, 1.3 for GH, and 1.1 for PRL. During 2005–2015, the overall incidence of CVD among PA patients was 6.6% (2106 cases), and the standardized incidence ratios were 4.1 for hemorrhagic stroke, 3.0 for ischemic stroke, and 1.7 for acute myocardial infarction. The standardized incidence ratios for stroke were significantly higher in the ACTH + TSH and NFPA groups, which also had higher risks of CVD-related mortality, relative to the PRL and GH groups. Conclusion: South Korea had a relatively high incidence of NFPA. The incidence of stroke was highest for ACTH + TSH and NFPA, which was directly related to mortality during long-term follow-up. Patients with these types of PA should receive stroke prevention measures to reduce their risk of mortality.
AB - Purpose: Few nationally representative studies have evaluated the epidemiology of PA (pituitary adenoma). This South Korean study evaluated the incidence of different PA subtypes, cardiovascular disease (CVD), and related mortality. Methods: This population-based study evaluated 31,898 patients with PA during 2005–2015. The incidence of PA, mortality, and CVD occurrence in PA cases were evaluated during a median follow-up of 5.3 years (range: 0–10 years). Cox regression analysis was used to evaluate the associations between CVD and mortality. Results: The annual incidences (per 100,000 population) were 3.5 for non-functioning pituitary adenoma (NFPA), 1.6 for prolactinoma (PRL), 0.5 for growth hormone-secreting pituitary adenoma (GH), and 0.2 for adrenocorticotropic or thyroid-stimulating hormone-secreting pituitary adenoma (ACTH + TSH). The standardized mortality ratios were 1.9 for ACTH + TSH, 1.7 for NFPA with hypopituitarism, 1.4 for NFPA without hypopituitarism, 1.3 for GH, and 1.1 for PRL. During 2005–2015, the overall incidence of CVD among PA patients was 6.6% (2106 cases), and the standardized incidence ratios were 4.1 for hemorrhagic stroke, 3.0 for ischemic stroke, and 1.7 for acute myocardial infarction. The standardized incidence ratios for stroke were significantly higher in the ACTH + TSH and NFPA groups, which also had higher risks of CVD-related mortality, relative to the PRL and GH groups. Conclusion: South Korea had a relatively high incidence of NFPA. The incidence of stroke was highest for ACTH + TSH and NFPA, which was directly related to mortality during long-term follow-up. Patients with these types of PA should receive stroke prevention measures to reduce their risk of mortality.
KW - Cardiovascular
KW - Incidence
KW - Mortality
KW - Pituitary neoplasm
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=85091082388&partnerID=8YFLogxK
U2 - 10.1007/s11102-020-01084-6
DO - 10.1007/s11102-020-01084-6
M3 - Article
C2 - 32949324
AN - SCOPUS:85091082388
SN - 1386-341X
VL - 24
SP - 38
EP - 47
JO - Pituitary
JF - Pituitary
IS - 1
ER -