Incidence, mortality, and cardiovascular diseases in pituitary adenoma in Korea: a nationwide population-based study

Jae Sang Oh, Hyun Jung Kim, Hoo Jae Hann, Tae Uk Kang, Dong Sook Kim, Min Ji Kang, Ji Young Lee, Jai Joon Shim, Man Ryul Lee, Hyeong Sik Ahn

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Purpose: Few nationally representative studies have evaluated the epidemiology of PA (pituitary adenoma). This South Korean study evaluated the incidence of different PA subtypes, cardiovascular disease (CVD), and related mortality. Methods: This population-based study evaluated 31,898 patients with PA during 2005–2015. The incidence of PA, mortality, and CVD occurrence in PA cases were evaluated during a median follow-up of 5.3 years (range: 0–10 years). Cox regression analysis was used to evaluate the associations between CVD and mortality. Results: The annual incidences (per 100,000 population) were 3.5 for non-functioning pituitary adenoma (NFPA), 1.6 for prolactinoma (PRL), 0.5 for growth hormone-secreting pituitary adenoma (GH), and 0.2 for adrenocorticotropic or thyroid-stimulating hormone-secreting pituitary adenoma (ACTH + TSH). The standardized mortality ratios were 1.9 for ACTH + TSH, 1.7 for NFPA with hypopituitarism, 1.4 for NFPA without hypopituitarism, 1.3 for GH, and 1.1 for PRL. During 2005–2015, the overall incidence of CVD among PA patients was 6.6% (2106 cases), and the standardized incidence ratios were 4.1 for hemorrhagic stroke, 3.0 for ischemic stroke, and 1.7 for acute myocardial infarction. The standardized incidence ratios for stroke were significantly higher in the ACTH + TSH and NFPA groups, which also had higher risks of CVD-related mortality, relative to the PRL and GH groups. Conclusion: South Korea had a relatively high incidence of NFPA. The incidence of stroke was highest for ACTH + TSH and NFPA, which was directly related to mortality during long-term follow-up. Patients with these types of PA should receive stroke prevention measures to reduce their risk of mortality.

Original languageEnglish
Pages (from-to)38-47
Number of pages10
Issue number1
StatePublished - Feb 2021

Bibliographical note

Funding Information:
This research was supported by Soonchunhyang University Fund and the Korean National Research Foundation grant funded by Korea government (Minister science and ICT) [NRF-2019M3E5D1A02069061& NRF-2020R1F1A1066362]. Acknowledgements

Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.


  • Cardiovascular
  • Incidence
  • Mortality
  • Pituitary neoplasm
  • Stroke


Dive into the research topics of 'Incidence, mortality, and cardiovascular diseases in pituitary adenoma in Korea: a nationwide population-based study'. Together they form a unique fingerprint.

Cite this