In vivo optical neural recording using fiber-based surface plasmon resonance

Shin Ae Kim, Sung June Kim, Hyowon Moon, Sang Beom Jun

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


We propose an intrinsic optical method for in vivo neural recording using optic fiber-based surface plasmon resonance (SPR) phenomena. The fiber-based SPR method is electrical artifact free, labeling free, and feasible for a portable system compared with conventional in vivo neural recording systems. We simultaneously detected SPR signals and electrical neural activity from the rat somatosensory cortex evoked by electrical stimulation on the forepaw. Pharmacological analysis using a voltage-gated sodium channel blocker confirmed the neural origins of the optical signals. This fiber-based SPR system promises the enhanced ability to record in vivo neural activity for the investigation of neurons and their networks.

Original languageEnglish
Pages (from-to)614-616
Number of pages3
JournalOptics Letters
Issue number4
StatePublished - 15 Feb 2012


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