Abstract
The in vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(l-lactic acid) (PGA/PLA) fibres and porous ultra-fine PGA fibres was investigated. The non-porous ultra-fine PGA/PLA fibres were prepared by electrospinning of a PGA/PLA solution in 1,1,1,3,3,3-hexafluoro-2-propanol and the porous ultra-fine PGA fibres were obtained from them via selective removal of PLA with chloroform. Since PLA has a lower degradation rate than PGA, the degradation rates of the ultra-fine PGA/PLA fibres decreased with increasing content of PLA. The porous ultra-fine PGA fibres were degraded in vitro in the order of non-porous PGA > P-PGA/PLA(90/10) > P-PGA/PLA(70/30) > P-PGA/PLA(50/50) > P-PGA/PLA(30/70) due to autocatalytic hydrolysis.
| Original language | English |
|---|---|
| Pages (from-to) | 441-448 |
| Number of pages | 8 |
| Journal | Polymer Degradation and Stability |
| Volume | 90 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 2005 |
Bibliographical note
Funding Information:This work was supported by the Ministry of Science and Technology, Korea.
Keywords
- Biodegradability
- Electrospinning
- Poly(glycolic acid)
- Poly(l-lactic acid)
- Porous ultra-fine fibre