In vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(l-lactic acid) fibres and porous ultra-fine poly(glycolic acid) fibres

Young You, Sung Won Lee, Ji Ho Youk, Byung Moo Min, Seung Jin Lee, Won Ho Park

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

The in vitro degradation behaviour of non-porous ultra-fine poly(glycolic acid)/poly(l-lactic acid) (PGA/PLA) fibres and porous ultra-fine PGA fibres was investigated. The non-porous ultra-fine PGA/PLA fibres were prepared by electrospinning of a PGA/PLA solution in 1,1,1,3,3,3-hexafluoro-2-propanol and the porous ultra-fine PGA fibres were obtained from them via selective removal of PLA with chloroform. Since PLA has a lower degradation rate than PGA, the degradation rates of the ultra-fine PGA/PLA fibres decreased with increasing content of PLA. The porous ultra-fine PGA fibres were degraded in vitro in the order of non-porous PGA > P-PGA/PLA(90/10) > P-PGA/PLA(70/30) > P-PGA/PLA(50/50) > P-PGA/PLA(30/70) due to autocatalytic hydrolysis.

Original languageEnglish
Pages (from-to)441-448
Number of pages8
JournalPolymer Degradation and Stability
Volume90
Issue number3
DOIs
StatePublished - Dec 2005

Keywords

  • Biodegradability
  • Electrospinning
  • Poly(glycolic acid)
  • Poly(l-lactic acid)
  • Porous ultra-fine fibre

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