In situ localization of p53, bcl-2 and bax mRNAs in rat ocular tissue

Dong Hoon Shin, Hwa Young Lee, Hye Won Lee, Hyun Joon Kim, Eunju Lee, Sa Sun Cho, Sang Ho Baik, Kyung Hoon Lee

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We mapped p53, bcl-2 and bax mRNAs, which are known to have correlation with apoptotic cell death, in the rat ocular tissue. p53 mRNA signals were present in several layers of retina, optic nerve, corneal epithelium, ciliary process and posterior surface of the iris. While almost the same pattern as p53 was recognized in the case of bcl-2 mRNA, bax signals were not found in ocular tissue except for ganglion cell layer (GCL). These results suggest that in the normal ocular tissue, p53 and bcl-2 genes play opposing parts in the physiological control of cell survival and death. A p53 mediated tumor- suppressing action might occur through the induction of transcriptional targets other than bax because only in GCL were p53 and bax mRNA expression co-localized.

Original languageEnglish
Pages (from-to)2165-2167
Number of pages3
JournalNeuroReport
Volume10
Issue number10
DOIs
StatePublished - 13 Jul 1999

Keywords

  • Bax
  • Bcl-2
  • Eye
  • In situ hybridization
  • p53
  • Rat

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