In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof

Byeongmoon Jeong; You Han Bae; Sung Wan Kim

doi:10.1002/(SICI)1097-4636(200005)50:2<171::AID-JBM11>3.0.CO;2-F

In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof

Byeongmoon Jeong, You Han Bae, Sung Wan Kim

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

263 Scopus citations

Abstract

Aqueous solutions of poly(ethylene glycol-b-[DL-lactic acid-co-glycolic acid]-b-ethylene glycol) (PEG-PLGA-PEG) triblock copolymers form a free- flowing sol at room temperature and become a gel at body temperature. In this study, in situ gel formation was investigated in rats. Upon subcutaneous injection of 33 wt % aqueous solutions of PEG-PLGA-PEG triblock copolymer into rats, transparent gels were observed. The gel showed good mechanical strength and the integrity of gels persisted longer than 1 month. The gel underwent degradation by hydrolysis and turned opaque. Degradation study showed preferential mass loss of PEG-rich segment from the in situ formed gel. Number average molecular weight determined by gel permeation chromatography decreased from 3300 to 1900 and 30% mass loss was observed over 1 month. (C) 2000 John Wiley and Sons, Inc.

Original language	English
Pages (from-to)	171-177
Number of pages	7
Journal	Journal of Biomedical Materials Research
Volume	50
Issue number	2
DOIs	https://doi.org/10.1002/(SICI)1097-4636(200005)50:2<171::AID-JBM11>3.0.CO;2-F
State	Published - 2000

Keywords

Biodegradable
In situ
Injectable
Sol-gel transition
Thermosensitivity

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10.1002/(SICI)1097-4636(200005)50:2<171::AID-JBM11>3.0.CO;2-F

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title = "In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof",

abstract = "Aqueous solutions of poly(ethylene glycol-b-[DL-lactic acid-co-glycolic acid]-b-ethylene glycol) (PEG-PLGA-PEG) triblock copolymers form a free- flowing sol at room temperature and become a gel at body temperature. In this study, in situ gel formation was investigated in rats. Upon subcutaneous injection of 33 wt % aqueous solutions of PEG-PLGA-PEG triblock copolymer into rats, transparent gels were observed. The gel showed good mechanical strength and the integrity of gels persisted longer than 1 month. The gel underwent degradation by hydrolysis and turned opaque. Degradation study showed preferential mass loss of PEG-rich segment from the in situ formed gel. Number average molecular weight determined by gel permeation chromatography decreased from 3300 to 1900 and 30% mass loss was observed over 1 month. (C) 2000 John Wiley and Sons, Inc.",

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N2 - Aqueous solutions of poly(ethylene glycol-b-[DL-lactic acid-co-glycolic acid]-b-ethylene glycol) (PEG-PLGA-PEG) triblock copolymers form a free- flowing sol at room temperature and become a gel at body temperature. In this study, in situ gel formation was investigated in rats. Upon subcutaneous injection of 33 wt % aqueous solutions of PEG-PLGA-PEG triblock copolymer into rats, transparent gels were observed. The gel showed good mechanical strength and the integrity of gels persisted longer than 1 month. The gel underwent degradation by hydrolysis and turned opaque. Degradation study showed preferential mass loss of PEG-rich segment from the in situ formed gel. Number average molecular weight determined by gel permeation chromatography decreased from 3300 to 1900 and 30% mass loss was observed over 1 month. (C) 2000 John Wiley and Sons, Inc.

AB - Aqueous solutions of poly(ethylene glycol-b-[DL-lactic acid-co-glycolic acid]-b-ethylene glycol) (PEG-PLGA-PEG) triblock copolymers form a free- flowing sol at room temperature and become a gel at body temperature. In this study, in situ gel formation was investigated in rats. Upon subcutaneous injection of 33 wt % aqueous solutions of PEG-PLGA-PEG triblock copolymer into rats, transparent gels were observed. The gel showed good mechanical strength and the integrity of gels persisted longer than 1 month. The gel underwent degradation by hydrolysis and turned opaque. Degradation study showed preferential mass loss of PEG-rich segment from the in situ formed gel. Number average molecular weight determined by gel permeation chromatography decreased from 3300 to 1900 and 30% mass loss was observed over 1 month. (C) 2000 John Wiley and Sons, Inc.

KW - Biodegradable

KW - In situ

KW - Injectable

KW - Sol-gel transition

KW - Thermosensitivity

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In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof

Abstract

Keywords

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