In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof

Byeongmoon Jeong, You Han Bae, Sung Wan Kim

Research output: Contribution to journalArticlepeer-review

240 Scopus citations

Abstract

Aqueous solutions of poly(ethylene glycol-b-[DL-lactic acid-co-glycolic acid]-b-ethylene glycol) (PEG-PLGA-PEG) triblock copolymers form a free- flowing sol at room temperature and become a gel at body temperature. In this study, in situ gel formation was investigated in rats. Upon subcutaneous injection of 33 wt % aqueous solutions of PEG-PLGA-PEG triblock copolymer into rats, transparent gels were observed. The gel showed good mechanical strength and the integrity of gels persisted longer than 1 month. The gel underwent degradation by hydrolysis and turned opaque. Degradation study showed preferential mass loss of PEG-rich segment from the in situ formed gel. Number average molecular weight determined by gel permeation chromatography decreased from 3300 to 1900 and 30% mass loss was observed over 1 month. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalJournal of Biomedical Materials Research
Volume50
Issue number2
DOIs
StatePublished - 2000

Keywords

  • Biodegradable
  • In situ
  • Injectable
  • Sol-gel transition
  • Thermosensitivity

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