In hot pursuit of the first vaccine against respiratory syncytial virus

Joo Young Kim, Jun Chang

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Human respiratory syncytial virus (RSV) is the leading cause of severe lower respiratory tract infection, such as bronchiolitis, bronchitis, or pneumonia, in both infants and the elderly. Despite the global burden of diseases attributable to RSV infection, no clinically approved vaccine is available, and a humanized monoclonal antibody for prophylaxis is not readily affordable in developing countries. There are several hurdles to the successful development of RSV vaccines: immune-vulnerable target populations such as premature infants, pregnant women, and immunocompromised people; safety concerns associated with vaccine-enhanced diseases; repeated infection; and waning memory. To develop successful strategies for the prevention of RSV infection, it is necessary to understand the protective and pathologic roles of host immune responses to RSV infection. In this review, we will summarize the positive and negative relationship between RSV infection and host immunity and discuss strategies for the development of the first successful RSV vaccine.

Original languageEnglish
Pages (from-to)809-816
Number of pages8
JournalYonsei Medical Journal
Volume57
Issue number4
DOIs
StatePublished - Jul 2016

Keywords

  • Immunity
  • Respiratory syncytial viruses
  • Vaccine
  • Vaccine-enhanced diseases

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