Improved reutilization of industrial crude lysine to 1,5-diaminopentane by enzymatic decarboxylation using various detergents and organic solvents

Hanyong Kim, Hah Young Yoo, Yong Hwan Ki, Il Kwon Kim, Eui Hong Byun, Yung Hun Yang, Si Jae Park, Jeong Geol Na, Hiesang Sohn, Taek Lee, Jung Rae Kim, Chulhwan Park

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

World-wide production of l-lysine has rapidly increased in recent years. In the industrial scale production, it is cost effective to minimize waste as many waste materials are generated during downstream processing. Therefore, the conversion of crude lysine to a more valuable product reduces waste emission. In this study, 1,5-diaminopentane (DAP, trivial name: cadaverine) was produced by l-lysine decarboxylation using Hafnia alvei. The conditions of enzymatic reaction were determined. In particular, the addition of specific detergent (Brij 56) was significantly affected in the bioconversion system. Addition of hydrophobic organic solvent improved the mixing of the reactants. Finally, an industrial crude form of lysine served as a substrate. The DAP conversion by analytical, feed and industrial crude l-lysine was 93.9%, 90.3%, and 63.8%, respectively.

Original languageEnglish
Pages (from-to)1854-1859
Number of pages6
JournalKorean Journal of Chemical Engineering
Volume35
Issue number9
DOIs
StatePublished - 1 Sep 2018

Bibliographical note

Funding Information:
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A1A09918327), the C1 Gas Refinery Program through NRF funded by the Ministry of Science and ICT (NRF-2018M3D3A1A01017991).

Publisher Copyright:
© 2018, Korean Institute of Chemical Engineers, Seoul, Korea.

Keywords

  • 1,5-Diaminopentane
  • Cadaverine
  • Decarboxylation
  • Detergent
  • Hafnia alvei
  • Lysine

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