Implementation of Procalcitonin in Antibiotic Stewardship: Derivation of a Consensus Algorithm for Procalcitonin Use in Clinical Practice

Dae Won Park, Jun Yong Choi, Chung Jong Kim, Jong Hun Kim, Hong Bin Kim, Dong Gun Lee

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Reducing antibiotics overuse is essential to minimize antibiotics related side effects and to prevent the emergence of multidrug-resistant bacteria. Procalcitonin (PCT) guided antibiotics therapy has been reported to be safe in patients with acute respiratory infections and sepsis, improving clinical outcomes as well as reducing the duration of antibiotics use. However, there is still no universal agreement on clinical guidelines in Korea for optimal PCT applications. Through this expert consensus meeting, clinical research findings in the PCT-guided antibiotics treatment interventions and real-world clinical applications were discussed. From the perspective of antibiotic stewardship, PCT application target groups, cut-offs, and testing cycles were discussed to reach a consensus on the PCT-guided antibiotics treatment algorithm for application in Korea. Combining clinical assessment for patients with an appropriate PCT-guided antibiotics treatment algorithm could improve the diagnosis and treatment of acute respiratory infections and sepsis. In addition, continuous education and regular feedback would improve the effectiveness of antibiotic stewardship.

Original languageEnglish
Pages (from-to)621-636
Number of pages16
JournalInfection and Chemotherapy
Volume54
Issue number4
DOIs
StatePublished - Dec 2022

Bibliographical note

Funding Information:
Roche Diagnostics Korea Supported the transcription of this expert consensus meeting and the English translation of the manuscript from the original Korean version.

Publisher Copyright:
© 2022 Korean Society for Antimicrobial Therapy. All rights reserved.

Keywords

  • Antibiotics
  • Antimicrobial Stewardship
  • Procalcitonin

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