Implantable wireless neural interface for multichannel neural recording and optogenetic neuromodulation

Daeho Ryu; Saeyoung Jeon; Yong Kweon Kim; Sang Beom Jun; Chang Hyeon Ji

doi:10.1109/OMN.2019.8925256

Implantable wireless neural interface for multichannel neural recording and optogenetic neuromodulation

Daeho Ryu, Saeyoung Jeon, Yong Kweon Kim, Sang Beom Jun, Chang Hyeon Ji

Electronic and Electrical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

This paper presents a low cost, light-weight, and low power consuming wireless neural interface for multichannel neural recording and optogenetic neuromodulation with 470 and 589 nm light sources and a customizable pulse generator. To enhance the light coupling efficiency between the light emitting diode (LED) and 4 x 4 array of optical fibers, microlens array is used. Measured light intensity at the tip of the fiber array is 2.812 and 1.765 mW/mm² for 470 and 589 nm light sources, respectively. Optical fibers are assembled with 4 x 4 microlens array on a silicon die, which enables the illumination of relatively large area in the brain. To record the neural signal, two zero-drift operational amplifiers and 12-bit ADC (analog-To-digital converter) were used. The sampling frequency on each channel is 16 kHz. A ± 160 μV, 100 Hz sine wave in saline solution was successfully measured and wirelessly transmitted with the fabricated device.

Original language	English
Title of host publication	OMN 2019 - 2019 International Conference on Optical MEMS and Nanophotonics, Proceedings
Publisher	IEEE Computer Society
Pages	8-9
Number of pages	2
ISBN (Electronic)	9781728145013
DOIs	https://doi.org/10.1109/OMN.2019.8925256
State	Published - Jul 2019
Event	2019 International Conference on Optical MEMS and Nanophotonics, OMN 2019 - Daejeon, Korea, Republic of Duration: 28 Jul 2019 → 1 Aug 2019

Publication series

Name	International Conference on Optical MEMS and Nanophotonics
Volume	2019-July
ISSN (Print)	2160-5033
ISSN (Electronic)	2160-5041

Conference

Conference	2019 International Conference on Optical MEMS and Nanophotonics, OMN 2019
Country/Territory	Korea, Republic of
City	Daejeon
Period	28/07/19 → 1/08/19

Bibliographical note

Funding Information:
ACKNOWLEDGMENT This work was supported by the Center for Integrated Smart Sensors funded by the Ministry of Science, ICT & Future Planning as Global Frontier Project (CISS-2012M3A6A6054204).

Publisher Copyright:
© 2019 IEEE.

Keywords

microlens array
neural recording
Optogenetics
wireless interface

Access to Document

10.1109/OMN.2019.8925256

Cite this

Ryu, D., Jeon, S., Kim, Y. K., Jun, S. B., & Ji, C. H. (2019). Implantable wireless neural interface for multichannel neural recording and optogenetic neuromodulation. In OMN 2019 - 2019 International Conference on Optical MEMS and Nanophotonics, Proceedings (pp. 8-9). Article 8925256 (International Conference on Optical MEMS and Nanophotonics; Vol. 2019-July). IEEE Computer Society. https://doi.org/10.1109/OMN.2019.8925256

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title = "Implantable wireless neural interface for multichannel neural recording and optogenetic neuromodulation",

abstract = "This paper presents a low cost, light-weight, and low power consuming wireless neural interface for multichannel neural recording and optogenetic neuromodulation with 470 and 589 nm light sources and a customizable pulse generator. To enhance the light coupling efficiency between the light emitting diode (LED) and 4 x 4 array of optical fibers, microlens array is used. Measured light intensity at the tip of the fiber array is 2.812 and 1.765 mW/mm2 for 470 and 589 nm light sources, respectively. Optical fibers are assembled with 4 x 4 microlens array on a silicon die, which enables the illumination of relatively large area in the brain. To record the neural signal, two zero-drift operational amplifiers and 12-bit ADC (analog-To-digital converter) were used. The sampling frequency on each channel is 16 kHz. A ± 160 μV, 100 Hz sine wave in saline solution was successfully measured and wirelessly transmitted with the fabricated device.",

keywords = "microlens array, neural recording, Optogenetics, wireless interface",

author = "Daeho Ryu and Saeyoung Jeon and Kim, \{Yong Kweon\} and Jun, \{Sang Beom\} and Ji, \{Chang Hyeon\}",

note = "Funding Information: ACKNOWLEDGMENT This work was supported by the Center for Integrated Smart Sensors funded by the Ministry of Science, ICT \& Future Planning as Global Frontier Project (CISS-2012M3A6A6054204). Publisher Copyright: {\textcopyright} 2019 IEEE.; 2019 International Conference on Optical MEMS and Nanophotonics, OMN 2019 ; Conference date: 28-07-2019 Through 01-08-2019",

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doi = "10.1109/OMN.2019.8925256",

language = "English",

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Ryu, D, Jeon, S, Kim, YK, Jun, SB & Ji, CH 2019, Implantable wireless neural interface for multichannel neural recording and optogenetic neuromodulation. in OMN 2019 - 2019 International Conference on Optical MEMS and Nanophotonics, Proceedings., 8925256, International Conference on Optical MEMS and Nanophotonics, vol. 2019-July, IEEE Computer Society, pp. 8-9, 2019 International Conference on Optical MEMS and Nanophotonics, OMN 2019, Daejeon, Korea, Republic of, 28/07/19. https://doi.org/10.1109/OMN.2019.8925256

Implantable wireless neural interface for multichannel neural recording and optogenetic neuromodulation. / Ryu, Daeho; Jeon, Saeyoung; Kim, Yong Kweon et al.
OMN 2019 - 2019 International Conference on Optical MEMS and Nanophotonics, Proceedings. IEEE Computer Society, 2019. p. 8-9 8925256 (International Conference on Optical MEMS and Nanophotonics; Vol. 2019-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Ji, Chang Hyeon

N1 - Funding Information: ACKNOWLEDGMENT This work was supported by the Center for Integrated Smart Sensors funded by the Ministry of Science, ICT & Future Planning as Global Frontier Project (CISS-2012M3A6A6054204). Publisher Copyright: © 2019 IEEE.

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N2 - This paper presents a low cost, light-weight, and low power consuming wireless neural interface for multichannel neural recording and optogenetic neuromodulation with 470 and 589 nm light sources and a customizable pulse generator. To enhance the light coupling efficiency between the light emitting diode (LED) and 4 x 4 array of optical fibers, microlens array is used. Measured light intensity at the tip of the fiber array is 2.812 and 1.765 mW/mm2 for 470 and 589 nm light sources, respectively. Optical fibers are assembled with 4 x 4 microlens array on a silicon die, which enables the illumination of relatively large area in the brain. To record the neural signal, two zero-drift operational amplifiers and 12-bit ADC (analog-To-digital converter) were used. The sampling frequency on each channel is 16 kHz. A ± 160 μV, 100 Hz sine wave in saline solution was successfully measured and wirelessly transmitted with the fabricated device.

AB - This paper presents a low cost, light-weight, and low power consuming wireless neural interface for multichannel neural recording and optogenetic neuromodulation with 470 and 589 nm light sources and a customizable pulse generator. To enhance the light coupling efficiency between the light emitting diode (LED) and 4 x 4 array of optical fibers, microlens array is used. Measured light intensity at the tip of the fiber array is 2.812 and 1.765 mW/mm2 for 470 and 589 nm light sources, respectively. Optical fibers are assembled with 4 x 4 microlens array on a silicon die, which enables the illumination of relatively large area in the brain. To record the neural signal, two zero-drift operational amplifiers and 12-bit ADC (analog-To-digital converter) were used. The sampling frequency on each channel is 16 kHz. A ± 160 μV, 100 Hz sine wave in saline solution was successfully measured and wirelessly transmitted with the fabricated device.

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EP - 9

BT - OMN 2019 - 2019 International Conference on Optical MEMS and Nanophotonics, Proceedings

PB - IEEE Computer Society

T2 - 2019 International Conference on Optical MEMS and Nanophotonics, OMN 2019

Y2 - 28 July 2019 through 1 August 2019

ER -

Ryu D, Jeon S, Kim YK, Jun SB , Ji CH. Implantable wireless neural interface for multichannel neural recording and optogenetic neuromodulation. In OMN 2019 - 2019 International Conference on Optical MEMS and Nanophotonics, Proceedings. IEEE Computer Society. 2019. p. 8-9. 8925256. (International Conference on Optical MEMS and Nanophotonics). doi: 10.1109/OMN.2019.8925256

Implantable wireless neural interface for multichannel neural recording and optogenetic neuromodulation

Abstract

Publication series

Conference

Bibliographical note

Keywords

Access to Document

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Cite this