Implantable optrode array for optogenetic modulation and electrical neural recording

Saeyeong Jeon, Youjin Lee, Daeho Ryu, Yoon Kyung Cho, Yena Lee, Sang Beom Jun, Chang Hyeon Ji

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several tech-nological advances in light delivery devices. Among them, the combination of optogenetics and electrophysiology provides an opportunity for facilitating optogenetic approaches. In this study, a novel design of an optrode array was proposed for realizing optical modulation and electrophys-iological recording. A 4 × 4 optrode array and five-channel recording electrodes were assembled as a disposable part, while a reusable part comprised an LED (light-emitting diode) source and a power line. After the characterization of the intensity of the light delivered at the fiber tips, in vivo animal experiment was performed with transgenic mice expressing channelrhodopsin, showing the effectiveness of optical activation and neural recording.

Original languageEnglish
Article number725
JournalMicromachines
Volume12
Issue number6
DOIs
StatePublished - Jun 2021

Keywords

  • Channelrhodopsin
  • Electrode
  • Electrophysiology
  • Optogenetics
  • Optrode

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