Implantable Neural Electrodes Fabrication Based on Perfluoroalkoxyalkane Film

Jisung Kim, Hee Soo Jeong, Sang Beom Jun, Jong Mo Seo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: In this paper, the fabrication of perfluoro-alkoxy alkane (PFA) film-based planar neural electrodes was proposed. Methods: The fabrication of PFA-based electrodes started with cleaning of PFA film. The argon plasma pretreatment was performed on the PFA film surface and attached to a dummy silicon wafer. Metal layers were deposited and patterned using the standard Micro Electro Mechanical Systems (MEMS) process. Electrode-sites and pads were opened using reactive ion etching (RIE). Lastly, the electrode patterned PFA substrate film was thermally laminated with the other bare PFA film. Electrical-physical evaluation tests were conducted along with in vitro tests, ex vivo tests and soak tests to evaluate the electrode performance and biocompatibility. Results: The electrical and physical performance of PFA-based electrodes had better performances compared to other biocompatible polymer-based electrodes. Also, the biocompatibility and longevity were verified by cytotoxicity test, elution test, and accelerated life test. Conclusion: The PFA film-based planar neural electrode fabrication was established and evaluated. The PFA based electrodes showed excellent benefits such as long-term reliability, low water absorption rate, and flexibility using the neural electrode. Significance: For implantable neural electrodes, hermetic sealing is required for in vivo durability. PFA fulfilled a low water absorption rate with relatively low Young's modulus to increase the longevity and biocompatibility of the devices.

Original languageEnglish
Pages (from-to)3-13
Number of pages11
JournalIEEE Transactions on Biomedical Engineering
Issue number1
StatePublished - 1 Jan 2024

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  • Fluoropolymer
  • implantable neural electrodes
  • neural prosthesis
  • perfluoro alkoxyalkane


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