Implantable Neural Electrodes Fabrication Based on Perfluoroalkoxyalkane Film

&#x00A0;Objective:In this paper, the fabrication of perfluoro-alkoxy alkane (PFA) film-based planar neural electrodes was proposed. Methods: The fabrication of PFA-based electrodes started with cleaning of PFA film. The argon plasma pretreatment was performed on the PFA film surface and attached to a dummy silicon wafer. Metal layers were deposited and patterned using the standard Micro Electro Mechanical Systems (MEMS) process. Electrode-sites and pads were opened using reactive ion etching (RIE). Lastly, the electrode patterned PFA substrate film was thermally laminated with the other bare PFA film. Electrical-physical evaluation tests were conducted along with <italic>in vitro</italic> tests, <italic>ex vivo</italic> tests and soak tests to evaluate the electrode performance and biocompatibility. Results: The electrical and physical performance of PFA-based electrodes had better performances compared to other biocompatible polymer-based electrodes. Also, the biocompatibility and longevity were verified by cytotoxicity test, elution test, and accelerated life test. Conclusion: The PFA film-based planar neural electrode fabrication was established and evaluated. The PFA based electrodes showed excellent benefits such as long-term reliability, low water absorption rate, and flexibility using the neural electrode. Significance: For implantable neural electrodes, hermetic sealing is required for <italic>in vivo</italic> durability. PFA fulfilled a low water absorption rate with relatively low Young&#x0027;s modulus to increase the longevity and biocompatibility of the devices.