TY - JOUR
T1 - Impact of short-term tinnitus treatment on cognitive function and neural synchronization
AU - Lee, Ho Yun
AU - Shin, Seung-Ho
AU - Byun, Sung Wan
N1 - Publisher Copyright:
Copyright © 2025 Lee, Shin and Byun.
PY - 2025
Y1 - 2025
N2 - We aimed to evaluate the impact of short-term tinnitus treatment on cognitive function and identify the effects of various treatment combinations on cognitive and tinnitus outcomes. A non-randomized prospective study was conducted with 32 tinnitus patients at a tertiary university hospital between May 2022 and May 2024. Patients received treatments, including neuromodulation, diuretics, gabapentin, selective serotonin reuptake inhibitors (SSRI), anxiolytics, muscle relaxants, hearing aids, and counseling. Cognitive function and tinnitus distress were assessed using the Mini-Mental State Examination (MMSE) and Tinnitus Handicap Inventory (THI) at baseline and 1 month after treatment. Quantitative electroencephalogram (qEEG) recordings were analyzed to evaluate changes in neural synchronization using phase-locking value (PLV). Strong correlations were also observed between baseline MMSE and changes in MMSE post-treatment (r = −0.796, p < 0.01) and between tinnitus loudness perception and changes in MMSE (r = 0.458, p < 0.01). After Bonferroni correction, muscle relaxants (p = 0.017) and neuromodulation (p = 0.007) showed significant negative effects on cognitive function, while anxiolytics demonstrated a tendency for negative effects (p = 0.052). Additionally, neither baseline tinnitus loudness nor changes in loudness perception (ΔVAS for loudness) were significantly correlated with ΔTHI after Bonferroni correction (p > 0.05). qEEG analysis showed increased PLV in prefrontal-limbic and parietal-occipital connections in patients with improved THI as well as increased PLV in temporal-limbic connections in patients with improved MMSE scores, indicating enhanced neural synchronization and cognitive resource reorganization. These findings underscore the need for careful consideration of cognitive effects when selecting tinnitus treatments and highlight the importance of targeted multimodal interventions to address both tinnitus distress and cognitive function.
AB - We aimed to evaluate the impact of short-term tinnitus treatment on cognitive function and identify the effects of various treatment combinations on cognitive and tinnitus outcomes. A non-randomized prospective study was conducted with 32 tinnitus patients at a tertiary university hospital between May 2022 and May 2024. Patients received treatments, including neuromodulation, diuretics, gabapentin, selective serotonin reuptake inhibitors (SSRI), anxiolytics, muscle relaxants, hearing aids, and counseling. Cognitive function and tinnitus distress were assessed using the Mini-Mental State Examination (MMSE) and Tinnitus Handicap Inventory (THI) at baseline and 1 month after treatment. Quantitative electroencephalogram (qEEG) recordings were analyzed to evaluate changes in neural synchronization using phase-locking value (PLV). Strong correlations were also observed between baseline MMSE and changes in MMSE post-treatment (r = −0.796, p < 0.01) and between tinnitus loudness perception and changes in MMSE (r = 0.458, p < 0.01). After Bonferroni correction, muscle relaxants (p = 0.017) and neuromodulation (p = 0.007) showed significant negative effects on cognitive function, while anxiolytics demonstrated a tendency for negative effects (p = 0.052). Additionally, neither baseline tinnitus loudness nor changes in loudness perception (ΔVAS for loudness) were significantly correlated with ΔTHI after Bonferroni correction (p > 0.05). qEEG analysis showed increased PLV in prefrontal-limbic and parietal-occipital connections in patients with improved THI as well as increased PLV in temporal-limbic connections in patients with improved MMSE scores, indicating enhanced neural synchronization and cognitive resource reorganization. These findings underscore the need for careful consideration of cognitive effects when selecting tinnitus treatments and highlight the importance of targeted multimodal interventions to address both tinnitus distress and cognitive function.
KW - cognition
KW - electroencephalogram
KW - neuromodulation
KW - tinnitus
KW - treatment
UR - http://www.scopus.com/inward/record.url?scp=86000598665&partnerID=8YFLogxK
U2 - 10.3389/fneur.2025.1478033
DO - 10.3389/fneur.2025.1478033
M3 - Article
AN - SCOPUS:86000598665
SN - 1664-2295
VL - 16
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 1478033
ER -
