TY - JOUR
T1 - Impact of multiple cardiovascular risk factors on the carotid intima-media thickness in young adults
T2 - The kangwha study
AU - Chang, Hoo Sun
AU - Kim, Hyeon Chang
AU - Ahn, Song Vogue
AU - Hur, Nam Wook
AU - Suh, Il
PY - 2007/9
Y1 - 2007/9
N2 - Objectives: Although risk factors for coronary artery disease are also associated with increased carotid intimamedia thickness (IMT), there is little information available on the asymptomatic, young adult population. We examined the association between multiple cardiovascular risk factors and the common carotid IMT in 280 young Korean adults. Methods: The data used for this study was obtained from 280 subjects (130 men and 150 women) aged 25 years who participated in the Kangwha Study follow-up examination in 2005. We measured cardiovascular risk factors, including anthropometrics, blood pressure, blood chemistry, carotid ultrasonography, and reviewed questionnaires on health behaviors. Risk factors were defined as values above the sex-specific 75th percentile of systolic blood pressure, body mass index, total cholesterol/high-density lipoprotein cholesterol ratio, fasting blood glucose and smoking status. Results: The mean carotid IMT!standard deviation observed was 0.683!0.079 mm in men and 0.678!0.067 mm in women (p=0.567) and the evidence of plaque was not observed in any individuals. Mean carotid IMT increased with an increasing number of risk factors(p for trend <0.001) and carotid IMT values were 0.665 mm, 0.674 mm, 0.686 mm, 0.702 mm, and 0.748 mm for 0, 1, 2, 3, and 4 to 5 risk factors, respectively. The odds ratio for having the top quartile carotid IMT in men with 3 or more risk factors versus 0-2 risk factors was 5.09 (95% CI, 2.05- 12.64). Conclusions: Current findings indicate the need for prevention and control of cardiovascular risk factors in young adults and more focus on those with multiple cardiovascular risk factors.
AB - Objectives: Although risk factors for coronary artery disease are also associated with increased carotid intimamedia thickness (IMT), there is little information available on the asymptomatic, young adult population. We examined the association between multiple cardiovascular risk factors and the common carotid IMT in 280 young Korean adults. Methods: The data used for this study was obtained from 280 subjects (130 men and 150 women) aged 25 years who participated in the Kangwha Study follow-up examination in 2005. We measured cardiovascular risk factors, including anthropometrics, blood pressure, blood chemistry, carotid ultrasonography, and reviewed questionnaires on health behaviors. Risk factors were defined as values above the sex-specific 75th percentile of systolic blood pressure, body mass index, total cholesterol/high-density lipoprotein cholesterol ratio, fasting blood glucose and smoking status. Results: The mean carotid IMT!standard deviation observed was 0.683!0.079 mm in men and 0.678!0.067 mm in women (p=0.567) and the evidence of plaque was not observed in any individuals. Mean carotid IMT increased with an increasing number of risk factors(p for trend <0.001) and carotid IMT values were 0.665 mm, 0.674 mm, 0.686 mm, 0.702 mm, and 0.748 mm for 0, 1, 2, 3, and 4 to 5 risk factors, respectively. The odds ratio for having the top quartile carotid IMT in men with 3 or more risk factors versus 0-2 risk factors was 5.09 (95% CI, 2.05- 12.64). Conclusions: Current findings indicate the need for prevention and control of cardiovascular risk factors in young adults and more focus on those with multiple cardiovascular risk factors.
KW - Atherosclerosis
KW - Cardiovascular disease
KW - Carotid arteries
KW - Risk factors
KW - Ultrasonography
KW - Young adult
UR - http://www.scopus.com/inward/record.url?scp=36048962685&partnerID=8YFLogxK
U2 - 10.3961/jpmph.2007.40.5.411
DO - 10.3961/jpmph.2007.40.5.411
M3 - Article
C2 - 17917490
AN - SCOPUS:36048962685
SN - 1975-8375
VL - 40
SP - 411
EP - 417
JO - Journal of Preventive Medicine and Public Health
JF - Journal of Preventive Medicine and Public Health
IS - 5
ER -